STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG5003FI05230p; It is involved in the biological process described with: regulation of cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle. (713 aa)    
Predicted Functional Partners:
CG30377
MIP13269p; It is involved in the biological process described with: copper ion homeostasis.
      
 0.835
CG14230
Probable RNA-binding protein CG14230; mRNA binding; RNA binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome.
   
  
 0.833
CG7154
LD22651p; Lysine-acetylated histone binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
    0.720
CG3342
GH18625p.
   
  
 0.718
Cul1
Cullin homolog 1; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. During early metamorphosis, part of the SCF-slmb complex that negatively regulates the InR/PI3K/TOR pathway to activate the pruning of unnecessary larv [...]
   
 
 0.693
IntS11
Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (By similarity). Mediates the snRNAs 3' cleavage (By similarity). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity); Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INT [...]
   
  
 0.678
CG10960
HL01062p; Carbohydrate:proton symporter activity. It is involved in the biological process described with: glucose import; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
      
 0.670
Cul6
Cullin 6; Ubiquitin-protein transferase activity; ubiquitin protein ligase binding; Belongs to the cullin family.
    
 
 0.660
tws
Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment.
   
   0.630
CAH2
Carbonic anhydrase 2 (CAH2) encodes an alpha-class carbonate dehydratase that catalyzes the reversible hydration/dehydration of carbon dioxide to bicarbonate and protons.
      
 0.626
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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