node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Capa | CapaR | FBpp0084880 | FBpp0078034 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | 0.925 |
Capa | Dh31 | FBpp0084880 | FBpp0079308 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | 0.689 |
Capa | ETH | FBpp0084880 | FBpp0072331 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality. | 0.713 |
Capa | Hug | FBpp0084880 | FBpp0082108 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.900 |
Capa | Lk | FBpp0084880 | FBpp0075465 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Leucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons. | 0.792 |
Capa | PK1-R | FBpp0084880 | FBpp0296961 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Pyrokinin-1 receptor; Receptor for the neuropeptide CAP-3/pyrokinin-1 (TGPSASSGLWFGPRL-amide). Also activated weakly by other neuropeptides terminating in the sequence PRL-amide including pyrokinin-2, Hug-gamma, and ecdysis-triggering-hormone-1. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. | 0.871 |
Capa | PK2-R2 | FBpp0084880 | FBpp0082241 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Pyrokinin 2 receptor 2 (PK2-R2) encodes a G protein-coupled receptor that binds the neuropeptide encoded by Hug with high affinity. After binding, a second messenger cascade is initiated in cells that are target for the product of Hug (mainly neurons of the central nervous system). | 0.752 |
Capa | Pdf | FBpp0084880 | FBpp0084396 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | PDF precursor-related peptide; Pigment-dispersing factor (Pdf) encodes a secreted biologically active neuropeptide that acts via a specific G-protein-coupled receptor to trigger intracellular signaling. It has a prominent role in the physiology of circadian rhythms, as well as contributing to other processes such as control of flight and digestion. | 0.631 |
Capa | aft | FBpp0084880 | FBpp0088518 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity). Regulates expression of tracheal genes required for pathfinding on the segmental nerve. | 0.669 |
Capa | sNPF | FBpp0084880 | FBpp0080859 | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.653 |
CapaR | Capa | FBpp0078034 | FBpp0084880 | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | 0.925 |
CapaR | Dh31 | FBpp0078034 | FBpp0079308 | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | 0.400 |
CapaR | ETH | FBpp0078034 | FBpp0072331 | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | Ecdysis triggering hormone (ETH) encodes two peptides (DrmETH1 and DrmETH2) involved in ecdysis. ETH depletion leads to respiratory and behavioral deficits, unsuccessful ecdysis and lethality. | 0.461 |
CapaR | Hug | FBpp0078034 | FBpp0082108 | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.660 |
CapaR | sNPF | FBpp0078034 | FBpp0080859 | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep. | 0.512 |
Dh31 | Capa | FBpp0079308 | FBpp0084880 | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | Cardio acceleratory peptide 2b; Capability (Capa) encodes three neuropeptides: two of the periviscerokinin family (CAPA-1 and CAPA-2) and one pyrokinin (pyrokinin-1) that activate the class A GPCRs encoded by CapaR and PK1-R respectively. Capa is expressed in neurosecretory cells innervating corpora cardiaca and abdomen. CAPA-1 and -2 act as diuretic hormones on the Malpighian tubules. | 0.689 |
Dh31 | CapaR | FBpp0079308 | FBpp0078034 | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | Neuropeptides capa receptor; Acts as a receptor for the neuropeptides CAP-1 and CAP-2, but not CAP-3. Probably a component of signal transduction pathway that leads to Malpighian tubule fluid secretion in response to these ligands. | 0.400 |
Dh31 | Hug | FBpp0079308 | FBpp0082108 | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | Protein hugin; Probably has a role in larval molting; Belongs to the pyrokinin family. | 0.447 |
Dh31 | Lk | FBpp0079308 | FBpp0075465 | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | Leucokinin (Lk) encodes a neuropeptide that regulates water balance and food intake. Three groups of leucokinergic neurons are identified in the brain and abdominal ganglion of larvae and adults. Serotonin and insulin peptides have receptors in the abdominal leucokinergic neurons. | 0.834 |
Dh31 | PK1-R | FBpp0079308 | FBpp0296961 | Diuretic hormone class 2; Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment. | Pyrokinin-1 receptor; Receptor for the neuropeptide CAP-3/pyrokinin-1 (TGPSASSGLWFGPRL-amide). Also activated weakly by other neuropeptides terminating in the sequence PRL-amide including pyrokinin-2, Hug-gamma, and ecdysis-triggering-hormone-1. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. | 0.430 |