STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hdcHeadcase short protein; Required for imaginal cell differentiation, may be involved in hormonal responsiveness during metamorphosis. Involved in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea. Regulated by transcription factor esg. The longer hdc protein is completely functional and the shorter protein carries some function. (1080 aa)    
Predicted Functional Partners:
CG8192
FI18007p1; Chitin binding. It is involved in the biological process described with: chitin metabolic process.
      
 0.835
unk
Unkempt (unk) encodes a highly conserved protein with roles in mRNA binding and ubiquitination. Together with the product of hdc, it acts downstream of the product of Mtor to regulate photoreceptor differentiation during eye development.
   
   0.827
Peritrophin-A
Peritrophin A, isoform A; Chitin binding. It is involved in the biological process described with: multicellular organism reproduction; chitin metabolic process.
      
 0.628
Chs2
Chitin synthase activity. It is involved in the biological process described with: cuticle chitin biosynthetic process.
   
  
 0.534
Fer2
48 related 2 (Fer2) encodes a bHLH-transcription factor required for the development of a subset of circadian pacemaker neurons and dopaminergic neurons in the protocerebral anterior medial (PAM) and the protocerebral anterior lateral clusters. It is also required for the survival of the PAM cluster dopaminergic neurons in adulthood.
      
 0.528
Mpcp1
Mitochondrial phosphate carrier protein 1, isoform A; Phosphate ion transmembrane transporter activity; inorganic phosphate transmembrane transporter activity. It is involved in the biological process described with: phosphate ion transport; phosphate ion transmembrane transport; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.438
Snx21
LD12265p; Phosphatidylinositol binding. It is involved in the biological process described with: protein transport.
   
  
 0.437
Mpcp2
Mitochondrial phosphate carrier protein 2, isoform A; Inorganic phosphate transmembrane transporter activity; phosphate ion transmembrane transporter activity. It is involved in the biological process described with: phosphate ion transmembrane transport; phosphate ion transport; wing disc dorsal/ventral pattern formation; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.420
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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