STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sap-rSaposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration. (953 aa)    
Predicted Functional Partners:
Gba1b
Glucosylceramidase; Glucocerebrosidase 1b (Gba1b) encodes a lysosomal acid beta glucocerebrosidase that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose.
   
 0.924
Manf
Mesencephalic astrocyte-derived neurotrophic factor (Manf) encodes an evolutionarily conserved neurotrophic factor. It contributes to dopamine neuron survival, regulation of unfolded protein response and retinal repair.
   
  
 0.901
Chc
Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles.
   
  
 0.788
CG8460
LD18607p; Oligosaccharide binding; chitin binding. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 18 family.
     
 0.750
Cp1
Cathepsin L heavy chain; Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion; Belongs to the peptidase C1 family.
   
 
 0.750
Lamp1
FI04419p; It is involved in the biological process described with: establishment of protein localization to organelle.
   
  
 0.739
cathD
CathD, isoform A; cathD (cathD) encodes a protein involved in apoptosis and the defense response to Gram-negative bacteria; Belongs to the peptidase A1 family.
   
 0.718
Prosbeta4R1
Proteasome subunit beta; Threonine-type endopeptidase activity; endopeptidase activity. It is involved in the biological process described with: proteasomal ubiquitin-independent protein catabolic process; proteasomal protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process.
      
 0.669
CG10086
RE33762p; It is involved in the biological process described with: protein transport.
      
 0.662
sel
Protein seele; Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing. Belongs to the canopy family.
      
 0.637
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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