STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Npc2hNiemann-Pick type C-2h (Npc2h) encodes a protein involved in immune signaling via interaction with lipopolysaccharides, lipid A, peptidoglycan and lipoteichoic acid. (157 aa)    
Predicted Functional Partners:
Npc2c
Niemann-Pick type C-2c; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport.
     
 0.982
Npc2e
Niemann-Pick type C-2e (Npc2e) encodes a protein involved in the immune signaling pathway via interaction with lipopolysaccharide, lipid A, peptidoglycan and lipoteichoic acid.
     
 0.982
Npc2a
NPC intracellular cholesterol transporter 2 homolog a; Functions redundantly with Npc2b in regulating sterol homeostasis and ecdysteroid biosynthesis, probably by controlling the availability of sterol substrate.
     
 0.966
Npc2b
Niemann-Pick type C-2b, isoform A; Sterol binding. It is involved in the biological process described with: multicellular organism reproduction; ecdysteroid biosynthetic process; intracellular cholesterol transport; sterol transport.
   
 
 0.966
Npc2g
Niemann-Pick type C-2g, isoform A; Sterol binding. It is involved in the biological process described with: intracellular cholesterol transport; sterol transport; mesoderm development.
  
 
0.945
Npc1a
Niemann-Pick type C-1a (Npc1a) encodes a cholesterol trafficking protein that contributes to sterol and ecdysone metabolism. It is involved in sperm individualization.
     
 0.937
Npc1b
NPC intracellular cholesterol transporter 1 homolog 1b; Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking. Belongs to the patched family.
     
  0.900
Npc2d
Niemann-Pick type C-2d; Sterol binding. It is involved in the biological process described with: sterol transport; intracellular cholesterol transport.
   
  
 0.792
Npc2f
Niemann-Pick type C-2f; Sterol binding. It is involved in the biological process described with: intracellular cholesterol transport; sterol transport.
   
  
 0.704
CG13325
GH20325p; Transferase activity, transferring acyl groups other than amino-acyl groups.
   
  
 0.537
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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