STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Alp4Alkaline phosphatase 4; Important role in neural and renal epithelial function. (596 aa)    
Predicted Functional Partners:
Pu
GTP cyclohydrolase 1; Isoform B is required for eye pigment production, Isoform C may be required for normal embryonic development and segment pattern formation.
   
 
  0.900
CG10581
IP06402p; Nucleotide phosphatase activity, acting on free nucleotides.
     
  0.900
CG14721
AT07857p; Thiamine diphosphokinase activity; ATP binding; thiamine binding. It is involved in the biological process described with: thiamine diphosphate biosynthetic process; thiamine metabolic process.
     
  0.900
pr
6-pyruvoyl tetrahydrobiopterin synthase; Required for pigment and biopterin synthesis. Belongs to the PTPS family.
     
  0.900
pigs
GAS2-like protein pickled eggs; Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons; Belongs to the GAS2 family.
      
 0.630
Eglp2
Entomoglyceroporin 2, isoform C; Water channel activity; channel activity. It is involved in the biological process described with: transmembrane transport; renal system process; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
  
 0.614
Irk3
Inwardly rectifying potassium channel 3 (Irk3) encodes a protein involved in wing disc development.
   
  
 0.551
Alp2
Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation.
  
 
 
0.531
Alp13
Alkaline phosphatase activity. It is involved in the biological process described with: dephosphorylation.
  
  
 
0.513
Gmap
Golgi microtubule-associated protein (Gmap) encodes a peripheral Golgi protein that is required for the efficient trafficking within the early secretory pathway, probably by recruiting Rab proteins and effector molecules.
   
 
  0.502
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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