| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CG14317 | CG7271 | FBpp0082965 | FBpp0074868 | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | RE03769p; Nucleic acid binding. | 0.896 |
| CG14317 | SNCF | FBpp0082965 | FBpp0075576 | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | 0.844 |
| CG14317 | Sry-alpha | FBpp0082965 | FBpp0312402 | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | Serendipity locus protein alpha; Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. | 0.564 |
| CG14317 | Z600 | FBpp0082965 | FBpp0075304 | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | Protein Z600; Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell poliferation allowing cell fate specification and morphogenesis [...] | 0.703 |
| CG14317 | bnk | FBpp0082965 | FBpp0085116 | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | Protein bottleneck; Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a la [...] | 0.579 |
| CG7271 | CG14317 | FBpp0074868 | FBpp0082965 | RE03769p; Nucleic acid binding. | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | 0.896 |
| CG7271 | SNCF | FBpp0074868 | FBpp0075576 | RE03769p; Nucleic acid binding. | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | 0.842 |
| CG7271 | Sry-alpha | FBpp0074868 | FBpp0312402 | RE03769p; Nucleic acid binding. | Serendipity locus protein alpha; Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. | 0.679 |
| CG7271 | Z600 | FBpp0074868 | FBpp0075304 | RE03769p; Nucleic acid binding. | Protein Z600; Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell poliferation allowing cell fate specification and morphogenesis [...] | 0.630 |
| CG7271 | bnk | FBpp0074868 | FBpp0085116 | RE03769p; Nucleic acid binding. | Protein bottleneck; Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a la [...] | 0.705 |
| CG7271 | nullo | FBpp0074868 | FBpp0288840 | RE03769p; Nucleic acid binding. | Protein nullo; Actin-myosin network stability during cellularization. Might be involved in increasing actin-actin interactions or membrane-to- cytoskeleton attachments. nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. | 0.498 |
| CG7271 | zld | FBpp0074868 | FBpp0074577 | RE03769p; Nucleic acid binding. | Zelda, isoform A; Zelda (zld) encodes a zinc finger transcription factor that functions in early blastoderm development. It works as a zygotic genome activator because it has a global role in regulating early expressed genes, such as genes essential for cellularization, sex determination and pattern formation. It is also required at later times in development. | 0.428 |
| SNCF | CG14317 | FBpp0075576 | FBpp0082965 | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | MIP30824p1; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. | 0.844 |
| SNCF | CG7271 | FBpp0075576 | FBpp0074868 | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | RE03769p; Nucleic acid binding. | 0.842 |
| SNCF | Sry-alpha | FBpp0075576 | FBpp0312402 | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | Serendipity locus protein alpha; Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. | 0.817 |
| SNCF | Z600 | FBpp0075576 | FBpp0075304 | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | Protein Z600; Cell cycle regulator that is involved in modulating and adjusting cell proliferation according to the requirements of the developmental program. Interacts with mitotic Cdk1-cyclin complexes to inhibit mitotic entry at the G2/M transition. Likely to function by binding to the hydrophobic patch of cyclins to interfere with the interaction between the complex and certain Cdk1 substrates. At the mid-blastula transition, involved in the cell cycle arrest in G2 of cycle 14 by delaying mitosis and thus reducing cell poliferation allowing cell fate specification and morphogenesis [...] | 0.778 |
| SNCF | bnk | FBpp0075576 | FBpp0085116 | SoxNeuro Co-Factor; Protein binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; regulation of localization. | Protein bottleneck; Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a la [...] | 0.563 |
| Spt | Sry-alpha | FBpp0288472 | FBpp0312402 | Spitting Image (Spt) encodes an F-actin binding and stabilizing protein. Spt and Sry-alpha represent a novel clade of the Vinculin/alpha-Catenin superfamily. The product of Spt is maternally provided in early embryos, and it positively regulates F-actin levels during cellularization. | Serendipity locus protein alpha; Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. | 0.917 |
| Spt | bnk | FBpp0288472 | FBpp0085116 | Spitting Image (Spt) encodes an F-actin binding and stabilizing protein. Spt and Sry-alpha represent a novel clade of the Vinculin/alpha-Catenin superfamily. The product of Spt is maternally provided in early embryos, and it positively regulates F-actin levels during cellularization. | Protein bottleneck; Acts as a regulator of the microfilament network governing cellularization of the embryo. Determines the timing of a key conformational transition in the cortical microfilament network: the proper coordination of membrane invagination and basal closure of the cells. To do this, bnk possibly physically links neighboring contractile units of the early cycle 14 microfilament network in a manner that prevents basal constriction until the proper stage has been reached. Bnk together with nullo and Sry-alpha may provide auxiliary functions, by acting both to stabilize a la [...] | 0.581 |
| Spt | nullo | FBpp0288472 | FBpp0288840 | Spitting Image (Spt) encodes an F-actin binding and stabilizing protein. Spt and Sry-alpha represent a novel clade of the Vinculin/alpha-Catenin superfamily. The product of Spt is maternally provided in early embryos, and it positively regulates F-actin levels during cellularization. | Protein nullo; Actin-myosin network stability during cellularization. Might be involved in increasing actin-actin interactions or membrane-to- cytoskeleton attachments. nullo together with Sry-a and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions. | 0.641 |
