STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
modDNA-binding protein modulo; Its capacity to bind DNA and protein(s), and its differential expression during development suggest a role in the regulation of gene expression during Drosophila development. It could, in interaction with other factors, be required for the translation of instructions provided by pattern forming genes and controls, via chromatin changes, the activity of genes critical for the process of morphogenesis of several embryonic territories. (542 aa)    
Predicted Functional Partners:
Anp
Andropin (Anp) encodes an antibacterial peptide expressed in the male genital tract; Belongs to the andropin family.
      
 0.824
CG9253
FI20110p1; RNA binding; RNA helicase activity; ATP binding. It is involved in the biological process described with: rRNA processing; Belongs to the DEAD box helicase family.
   
    0.807
CG5033
Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.
   
    0.806
Nnp-1
Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA; Belongs to the RRP1 family.
   
    0.801
Nlp
Nucleoplasmin-like protein; Binds to core histones and functions in the ATP-facilitated assembly of approximately regularly spaced nucleosomal arrays. May participate in parallel with other histone-binding proteins such as NAP-1; Belongs to the nucleoplasmin family.
   
   0.797
eEF1delta
Probable elongation factor 1-delta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.
   
    0.750
nop5
CG10206-PA; snoRNA binding. It is involved in the biological process described with: rRNA processing.
   
    0.732
CG8545
LD11307p; RNA binding; rRNA (cytosine-C5-)-methyltransferase activity. It is involved in the biological process described with: maturation of LSU-rRNA; RNA methylation; rRNA base methylation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
   
    0.715
NHP2
H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).
   
    0.715
Tsr1
Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.
   
    0.712
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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