STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
TbceTubulin-specific chaperone E; Tubulin-folding protein which is required for the development of the neuronal microtubule network. Essential for the development and function of neuromuscular synapses. Likely to promote microtubule formation by acting in the negative regulation of the microtubule- severing protein spas; Belongs to the TBCE family. (523 aa)    
Predicted Functional Partners:
TBCD
Tubulin folding cofactor D (TBCD) encodes one of the tubulin folding cofactors, which assist in the formation of tubulin heterodimers. It cooperates with the product of Dscam1 to regulate microtubule organization during neural development.
   
 
 0.991
TBCC
Tubulin-binding cofactor C, isoform A; Tubulin binding. It is involved in the biological process described with: tubulin complex assembly; protein folding; post-chaperonin tubulin folding pathway; cell morphogenesis.
    
 
 0.936
Arl2
ADP ribosylation factor-like 2 (Arl2) encodes a small GTPase within the ADP-ribosylation factor-like family. Arl2 product functions as a central regulator of microtubule growth and asymmetric division of neuroblasts.
   
 
 0.910
TBCB
Tubulin-binding cofactor B (TBCB) encodes one of the cofactors required for the assembly of functional alpha/beta-Tubulin dimers needed for microtubule assembly. It is essential for microtubule-associated transport and cell polarity, but not for cell division.
   
 
0.857
CG1890
Tubulin-specific chaperone A; Beta-tubulin binding; tubulin binding. It is involved in the biological process described with: post-chaperonin tubulin folding pathway; tubulin complex assembly; protein folding; Belongs to the TBCA family.
    
 
 0.826
betaTub56D
Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.
    
 
 0.751
spas
Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily.
   
  
 0.613
CG13653
Uncharacterized protein.
      
 0.609
Samuel
SAM-motif ubiquitously expressed punctatedly localized protein (Samuel) encodes a protein that binds to the nuclear receptor encoded by Hr78 and acts as a corepressor. It regulates chromatin silencing and larval growth.
      
 0.606
Lis-1
Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...]
   
 
 0.556
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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