STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCHa2-RNeuropeptide CCHamide-2 receptor; Receptor for the neuropeptide CCHamide-2. Belongs to the G-protein coupled receptor 1 family. (501 aa)    
Predicted Functional Partners:
CCHa1-R
Neuropeptide CCHamide-1 receptor; Receptor for the neuropeptide CCHamide-1. Plays a role in the modulation of starvation-induced olfactory behavior where starved flies show increased responsiveness to food odorants, repellants and pheromones.
  
 
0.922
CCHa2
Neuropeptide CCHamide-2; Ligand for the CCHamide-2 receptor CCHa2-R. In one study, shown to be an orexigenic peptide which induces appetite and stimulates food intake, leading to the release of insulin-like peptides which stimulate growth. In another study, shown to be a nutrient-sensitive peptide derived from peripheral tissues which controls growth by directly regulating the production and release of insulin-like peptides.
      
 0.896
CCHa1
Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R.
      
 0.679
Ilp5
Insulin-like peptide 5 (Ilp5) encodes a peptide involved in the insulin signaling pathway, sleep and mating behavior in females; Belongs to the insulin family.
      
 0.609
CG9467
LD44003p; Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: protein homooligomerization; oxidation-reduction process.
      
 0.532
CG8460
LD18607p; Oligosaccharide binding; chitin binding. It is involved in the biological process described with: carbohydrate metabolic process; Belongs to the glycosyl hydrolase 18 family.
      
 0.530
Diap2
Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]
      
 0.489
SIFa
Neuropeptide SIFamide; Ligand for the neuropeptide SIFamide receptor. Modulates sexual behavior by negatively regulating female receptivity to male courtship and by playing a role in male sex discrimination. Also involved in promoting sleep. Belongs to the FARP (FMRFamide related peptide) family.
   
  
 0.487
dmrt99B
Doublesex-Mab related 99B; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
  
 0.473
CG3106
GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.
      
 0.468
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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