| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Bx | Chi | FBpp0309325 | FBpp0072101 | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance. | 0.996 |
| Bx | Ssdp | FBpp0309325 | FBpp0303084 | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. | 0.743 |
| Bx | ap | FBpp0309325 | FBpp0085394 | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | 0.847 |
| Bx | fng | FBpp0309325 | FBpp0077925 | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | Fringe glycosyltransferase; Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta- 1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development. | 0.871 |
| Catsup | ap | FBpp0080687 | FBpp0085394 | Protein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | 0.604 |
| Chi | Bx | FBpp0072101 | FBpp0309325 | Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance. | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | 0.996 |
| Chi | Ssdp | FBpp0072101 | FBpp0303084 | Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance. | Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. | 0.999 |
| Chi | ap | FBpp0072101 | FBpp0085394 | Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance. | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | 0.953 |
| Ssdp | Bx | FBpp0303084 | FBpp0309325 | Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | 0.743 |
| Ssdp | Chi | FBpp0303084 | FBpp0072101 | Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. | Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance. | 0.999 |
| Ssdp | ap | FBpp0303084 | FBpp0085394 | Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | 0.727 |
| acj6 | ap | FBpp0073832 | FBpp0085394 | Inhibitory POU protein; Modulates gene transcription; simultaneously generates both a specific activator and an inhibitor of gene transcription, capable of modulating two distinct regulatory programs during neural development. Has a role in olfactory behavior; Belongs to the POU transcription factor family. Class-4 subfamily. | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | 0.560 |
| ap | Bx | FBpp0085394 | FBpp0309325 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Beadex, isoform D; Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. | 0.847 |
| ap | Catsup | FBpp0085394 | FBpp0080687 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Protein catecholamines up; Negatively regulates tyrosine hydroxylase activity; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. | 0.604 |
| ap | Chi | FBpp0085394 | FBpp0072101 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Chip, isoform B; Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance. | 0.953 |
| ap | Ssdp | FBpp0085394 | FBpp0303084 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes. | 0.727 |
| ap | acj6 | FBpp0085394 | FBpp0073832 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Inhibitory POU protein; Modulates gene transcription; simultaneously generates both a specific activator and an inhibitor of gene transcription, capable of modulating two distinct regulatory programs during neural development. Has a role in olfactory behavior; Belongs to the POU transcription factor family. Class-4 subfamily. | 0.560 |
| ap | bor | FBpp0085394 | FBpp0082728 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | ATPase family AAA domain-containing protein 3A homolog; Required to maintain the proper number of mitochondria in neurons and muscles. | 0.600 |
| ap | fng | FBpp0085394 | FBpp0077925 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Fringe glycosyltransferase; Glycosyltransferase involved in the elongation of O-linked ligands to activate Notch signaling. Possesses fucose-specific beta- 1,3-N-acetylglucosaminyltransferase activity; extends the O-linked fucose on the Notch EGF repeats. Boundary-specific cell-signaling molecule that is responsible for dorsal-ventral cell interactions during wing development. | 0.820 |
| ap | kn | FBpp0085394 | FBpp0111722 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Transcription factor collier; May act as a 'second-level regulator' of head patterning. Required for establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment. Required for expression of the segment polarity genes hedgehog, engrailed and wingless, and the segment-identity genes CAP and collar in the intercalary segment. Required at the onset of the gastrulation for the correct formation of the mandibular segment. | 0.590 |