STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG30440LD43457p; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of Rho protein signal transduction. (1057 aa)    
Predicted Functional Partners:
CG42674
Uncharacterized protein, isoform C; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: positive regulation of Rho protein signal transduction; imaginal disc-derived leg morphogenesis.
      
 0.697
cyst
Uncharacterized protein, isoform C; Rho guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Rho protein signal transduction; positive regulation of Rho protein signal transduction.
   
  
 0.673
Cht10
Probable chitinase 10; Chitinase activity; chitin binding. It is involved in the biological process described with: carbohydrate metabolic process; chitin catabolic process.
   
    0.632
CG6424
Uncharacterized protein, isoform A.
      
 0.619
side-III
Sidestep III, isoform O.
   
  
 0.604
side-II
Sidestep II, isoform A.
   
  
 0.603
CdGAPr
Cd GTPase activating protein-related (CdGAPr) encodes a protein that acts in concert with the product of Fak in the formation of the optic stalk, a tubular structure composed of glial cells.
   
  
 0.602
Sos
Protein son of sevenless; Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.
  
   
 0.536
PsGEF
Protostome-specific GEF, isoform E.
   
  
 0.529
RhoGAPp190
Rho GTPase-activating protein 190; GTPase-activating protein (GAP) for RhoA/Rho1 that plays an essential role in the stability of dorsal branches of mushroom body (MB) neurons. The MB neurons are the center for olfactory learning and memory. Acts by converting RhoA/Rho1 to an inactive GDP-bound state, leading to repress the RhoA/Rho1-Drok-MRLC signaling pathway thereby maintaining axon branch stability.
   
  
 0.500
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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