STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG9436LD24696p; alditol:NADP+ 1-oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process. (311 aa)    
Predicted Functional Partners:
CG7322
RH57257p; Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; carbonyl reductase (NADPH) activity; L-xylulose reductase (NADP+) activity. It is involved in the biological process described with: xylulose metabolic process; glucose metabolic process.
   
 
 0.949
Sodh-1
Sorbitol dehydrogenase 1, isoform A; Zinc ion binding; L-iditol 2-dehydrogenase activity. It is involved in the biological process described with: oxidation-reduction process; sorbitol catabolic process.
  
 0.928
Sodh-2
Sorbitol dehydrogenase-2; L-iditol 2-dehydrogenase activity; zinc ion binding. It is involved in the biological process described with: oxidation-reduction process; sorbitol catabolic process.
  
 0.928
Dhpr
NADH binding; NADPH binding; 6,7-dihydropteridine reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process; L-phenylalanine catabolic process.
  
 0.917
Dhfr
Dihydrofolate reductase (Dhfr) encodes an NADPH-dependent enzyme used to convert folic acid and dihydrofolate to tetrahydrofolate, which is used as a cofactor for the biosynthesis of purines, thymidylate, and several amino acids. Dhfr product contributes to cell proliferation and cell growth.
  
 
 0.914
Sptr
Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin.
  
 
 0.912
CG12116
RE21057p; Sepiapterin reductase activity. It is involved in the biological process described with: tetrahydrobiopterin biosynthetic process.
  
 
 0.908
GstO3
Glutathione S-transferase omega class; Glutathione S transferase O3 (GstO3) encodes a transferase involved in glutathione metabolism; Belongs to the GST superfamily.
   
 0.905
se
Pyrimidodiazepine synthase; Mediates the conversion of 2-amino-4-oxo-6-pyruvoyl-5,6,7,8- tetrahydropteridine (6-PTP; also named 6-pyruvoyltetrahydropterin) to 2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido(4,5-b)[1,4]diazepin-4- one (pyrimidodiazepine or PDA), a key intermediate in red eye pigment drosopterin biosynthesis.
    
 0.903
Gal
Beta galactosidase (Gal) encodes a putative digestive enzyme that hydrolyses beta-galactosides into monosaccharides. Gal is highly expressed and enriched in the midgut, an organ involved in digestion; Belongs to the glycosyl hydrolase 35 family.
  
 
  0.903
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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