STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Spn42DaSerpin 42Da, isoform B; Serpin 42Da (Spn42Da) encodes an endopeptidase inhibitor involved in hormone processing regulation; Belongs to the serpin family. (424 aa)    
Predicted Functional Partners:
Papss
PAPS synthetase (Papss) encodes an enzyme that catalyzes the synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), the sulfate donor compound in all sulfotransferase reactions. Maternally provided Papss product is required for the formation of the embryonic dorsal-ventral axis mediated by the sulfotransferase encoded by pip.
      
 0.790
Spn77Ba
Serine protease inhibitor 77Ba; Serine protease inhibitor which plays an essential role in regulating the tracheal melanization immune response to bacterial and fungal infection. Acts by negatively regulating a protease cascade involving Mp1 and Sp7, that functions in the activation of the Hayan-phenoloxidase (PPO1) cascade ; Belongs to the serpin family.
  
 
0.685
Fur1
Furin-like protease 1, isoforms 1/1-X/2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
   
  
 0.679
Fur2
Furin-like protease 2; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.
   
  
 0.672
Spn88Ea
Serine protease inhibitor 88Ea; Serine protease inhibitor with activity toward trypsin. Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin. Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade. Essential for unfolding and expansion of the wings after emergence from the pupal case. May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz.
  
0.671
Spn28Dc
Serine protease inhibitor 28Dc; Serine protease inhibitor which is required for pupal viability and plays an essential role in regulating the melanization reaction. Inhibits spontaneous melanization and appears to be involved in the melanization immune response to physical wounding in larvae and adults. Acts by negatively regulating the Hayan-phenoloxidase (PPO1) cascade in the hemolymph and possibly the trachea. May function by controlling the initial release of the activated form of PPO1, phenoloxidase (PO) and thus maintains PO availability for processes such as wound response and p [...]
  
 
0.667
PPO1
Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan.
   
  
 0.631
Spn27A
Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...]
  
 
0.631
Spn75F
Male accessory gland protein; Serine-type endopeptidase inhibitor activity. It is involved in the biological process described with: negative regulation of endopeptidase activity; multicellular organism reproduction; Belongs to the serpin family.
  
  
0.615
CG18179
RE53819p; Serine-type endopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the peptidase S1 family.
    
 
 0.608
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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