STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
galla-1MIP18 family protein galla-1; Component of the crb-galla-Xpd (CGX) complex which is essential for proper mitotic chromosome segregation in early embryos. The CGX complex is also required for cell proliferation in developing wing disks. In the CGX complex, acts with crb to recruit Xpd thus forming the functional complex; Belongs to the MIP18 family. (218 aa)    
Predicted Functional Partners:
Mms19
GH06271p; It is involved in the biological process described with: iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer.
    
 
 0.993
Ciao1
Probable cytosolic iron-sulfur protein assembly protein Ciao1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
   
 
 0.988
Xpd
Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH.
    
 
 0.837
CG17683
Probable cytosolic Fe-S cluster assembly factor CG17683; Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity); Belongs to the NARF family.
    
 
 0.754
CIAPIN1
Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]
      
 0.750
Lnpk
Lunapark, isoform A; It is involved in the biological process described with: endoplasmic reticulum tubular network organization.
   
  
 0.664
CG10082
Kinase activity; inositol hexakisphosphate kinase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate biosynthetic process; Belongs to the inositol phosphokinase (IPK) family.
   
  
 0.663
Coop
Corepressor of Pangolin (Coop) encodes a protein that represses gene expression mediated by Wg signaling. It binds to the product of pan preventing the interaction of the products of pan with arm. By antagonizing Wg signaling, it contributes to patterning and cell fate decisions during development.
      
 0.609
CG1273
RE03558p.
      
 0.600
crb
Protein crumbs; Plays a central role in cell polarity establishment. Participates in the assembly, positioning and maintenance of adherens junctions via its interaction with the SAC complex. Controls the coalescence of the spots of zonula adherens (ZA) into a adhesive ring around the cells. It may act as a signal. Involved in morphogenesis of the photoreceptor rhabdomere, for positioning and growth of rhabdomere and AJ during the crucial period of photoreceptor extension along the proximodistal axis of the retina. Component of the crb-galla-Xpd (CGX) complex which is essential for prop [...]
    
 
 0.579
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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