Pan gu (png) encodes a Ser/Thr kinase that controls the translation of hundreds of mRNAs, such as CycB and smg, during the oocyte-to-embryo transition. The activation of the product of png requires the formation of a complex with the two activating subunits encoded by plu and gnu.

Mitosis initiation protein fs(1)Ya; Female sterile (1) Young arrest (fs(1)Ya) encodes a maternally-expressed protein that is required for mitotic phase initiation during early embryogenesis. It localizes in the nuclear lamina of the embryo, and binds DNA and the product of His2B. In developing oocytes the product of fs(1)Ya is cytoplasmic, but enters nuclei when it is dephosphorylated during egg activation.

Homeotic protein bicoid; Segment polarity protein that provides positional cues for the development of head and thoracic segments. Regulates the expression of zygotic genes, possibly through its homeodomain, and inhibits the activity of other maternal gene products. May also bind RNA. Interacts with Bin1 to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction.

Male sterile (3) K81 (ms(3)K81) encodes a telomere capping protein that is required to protect sperm telomeres from end-to-end fusion at fertilization. The ms(3)K81 product replaces its paralog HipHop in post-meiotic male germ cell nuclei.

Poly(A) RNA polymerase gld-2 homolog B; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific maternal RNAs (bcd, Tl, and tor), forming a poly(A) tail, during late oogenesis and early embryogenesis. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Required for localization of mRNAs to both poles of the egg, to recruit or maintain known centrosomal proteins with two types of microtubule organizing centers (MTOCs): the central MTOC that forms between the meiosis II tandem spindles and [...]

Early boundary activity protein 2; The heterotrimeric Elba complex is required for chromatin domain boundary function during early embryogenesis. It binds to a 8-bp sequence 5'-CCAATAAG-3' in the Fab-7 insulator or boundary element in the bithorax complex and contributes to its insulator or boundary activity. Elba2 can act as a transcriptional repressor and binds the palindromic sequence 5'-CCAATTGG-3' to mediate transcriptional repression.

G2/mitotic-specific cyclin-B; Cyclin B (CycB) encodes a protein that binds to Cdk1, thereby promoting Cdk1's protein kinase activity. The complex CycB-Cdk1 complex induces the start of mitosis. During late metaphase of mitosis and continuing in G1, the product of CycB is rapidly degraded (involving APC/C and the proteasome), resulting in inactivation of Cdk1 protein kinase activity, and allowing termination of mitosis.

LD21346p.

Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the mother centriole cylinder, using mother centriole as a platform, leading to the recruitment of centriole biogenesis proteins such as Sas-6. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Centrosome amplification following overexpression can initiate tumorigenesis, highlighting [...]