STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wblWindbeutel (wbl) encodes a Toll signaling pathway member protein residing in the endoplasmic reticulum. It is required for the transport of the product of pip to the Golgi in ovarian follicle cells. (257 aa)    
Predicted Functional Partners:
CaBP1
Protein disulfide-isomerase A6 homolog; Calcium-binding protein 1 (CaBP1) encodes a protein that resides in the lumen of the endoplasmic reticulum. It seems to be relocated outside cells during apoptosis and involved in the phagocytosis of apoptotic cells.
   
 0.929
prtp
Thioredoxin domain-containing protein 5 homolog; Possesses thioredoxin activity (By similarity). Acts as a ligand for Drpr and is required for the phagocytosis of apoptotic cells. Binds to the extracellular region of Drpr and augments Drpr tyrosine phosphorylation ; Belongs to the protein disulfide isomerase family.
   
 0.922
Pdi
Protein disulfide-isomerase; Participates in the folding of proteins containing disulfide bonds.
   
 0.922
Ero1L
Ero1-like protein; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity); Belongs to the EROs family.
     
 0.921
CG18132
IP08350p; It is involved in the biological process described with: cell redox homeostasis; apoptotic cell clearance.
   
 0.915
CG31698
GEO09046p1.
      
 0.665
CG31643
LD32258p; Protein kinase activity.
      
 0.662
CG14868
RH63657p.
      
 0.659
CG9338
GEO04151p1.
      
 0.659
CG11857
Uncharacterized protein, isoform C; It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; protein retention in ER lumen.
   
  
 0.656
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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