STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vps51Vacuolar protein sorting-associated protein 51 homolog; May act as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans- Golgi network (TGN); Belongs to the VPS51 family. (740 aa)    
Predicted Functional Partners:
Vps53
Vacuolar protein sorting 53; It is involved in the biological process described with: retrograde transport, endosome to Golgi; endocytic recycling.
   
 0.999
Vps52
Vacuolar protein sorting 52; Rab GTPase binding; syntaxin binding. It is involved in the biological process described with: retrograde transport, endosome to Golgi; lysosomal transport; Golgi to vacuole transport; endocytic recycling.
   
 0.999
Vps50
Vacuolar protein sorting 50; It is involved in the biological process described with: endocytic recycling; retrograde transport, endosome to Golgi.
   
 0.998
scat
Vacuolar protein sorting-associated protein 54; May be involved in retrograde transport from early and late endosomes to late Golgi (By similarity). Required during spermatogenesis for sperm individualization; Belongs to the VPS54 family.
   
 0.984
Syx6
Syntaxin 6, isoform E; SNARE binding; SNAP receptor activity.
    
 0.973
CG10646
RH33377p; It is involved in the biological process described with: protein ubiquitination.
   
 
 0.912
fws
Conserved oligomeric Golgi complex subunit 5; Four way stop (fws) encodes a protein localised to the Golgi apparatus and involved in several aspects of spermatogenesis. Loss of function of fws causes failure of cleavage furrow ingression in dividing spermatocytes, as well as failure of cell elongation and disruption of the Golgi-based acroblast during spermatid differentiation.
   
 
 0.896
Syx16
Syntaxin 16 (Syx16) encodes a member of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. It is localized to late Golgi compartments and is part of a trans-SNARE complex responsible for endosome-to-Golgi/trans Golgi network retrograde transport.
    
 0.895
Cog1
Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function.
   
 
 0.883
Arl5
ADP-ribosylation factor-like 5 (Arl5) encodes a protein involved in endosome-to-Golgi trafficking; Belongs to the small GTPase superfamily. Arf family.
   
 
 0.862
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.