STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BomS3Bomanin-3; Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance bacterial and fungal infections. The strength of antimicrobial activity appears to correlate with the overall level of expression. Has no activity against the fungus C.glabrata in vitro ; Belongs to the bomanin family. (39 aa)    
Predicted Functional Partners:
Dso1
Immune-induced peptide 4; It is involved in the biological process described with: defense response; cell morphogenesis; humoral immune response; response to bacterium.
   
 
 0.996
BomS2
Bomanin-2; Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections.
   
 
0.993
BomS1
Bomanin-1; Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections. Has no activity against the fungus C.glabrata in vitro.
   
 
0.990
BomT2
Bomanin-836; Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections. The strength of antimicrobial activity appears to correlate with the overall level of expression. Belongs to the bomanin family.
   
  
 0.949
BomBc1
Bomanin-23; Secreted immune-induced peptide induced by Toll signaling. Has a role in resistance to bacterial and fungal infections. Belongs to the bomanin family.
   
  
 0.939
BomBc2
Uncharacterized protein, isoform A.
   
  
 0.912
Dif
Dorsal-related immunity factor Dif; Mediates an immune response in larvae. DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1. Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that downregulates Spn27A in response to infection. Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates dev [...]
     
 0.906
dl
Embryonic polarity protein dorsal; Embryonic developmental protein. The lateral or ventral identity of a cell depends upon the concentration of this protein in its nucleus during the blastoderm stage. A morphogenetic protein that specifically binds to the kappa B-related consensus sequence 5'- GRGAAAANCC-3', located in the enhancer region of zygotic genes such as Zen, Twist, Snail and Decapentaplegic. Mediates an immune response in larvae. Part of a signaling pathway involving NF- kappa-B and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition [...]
   
 
  0.900
GNBP-like3
GNBP-like 3; Carbohydrate binding. It is involved in the biological process described with: defense response to other organism; detection of biotic stimulus; response to fungus.
   
  
 0.865
CG33470
Immune-induced peptide 10; May be involved in the Toll signaling pathway.
   
  
 0.864
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.