STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG17669Dynein assembly factor 3, axonemal homolog; Required for the assembly of axonemal inner and outer dynein arms; Belongs to the DNAAF3 family. (540 aa)    
Predicted Functional Partners:
Zmynd10
Zinc finger MYND domain-containing protein 10 homolog; Plays a role in axonemal structure organization and motility. May be involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility; Belongs to the ZMYND10 family.
   
  
 0.849
CG34242
IP16893p; It is involved in the biological process described with: mitochondrial cytochrome c oxidase assembly.
   
 
 0.847
up
Troponin T, skeletal muscle; Upheld (up) encodes the striated muscle protein Troponin T. Troponins T, C and I form a regulatory complex with Tropomyosin that is found at regular intervals along the thin (F-actin) filaments of the muscle sarcomere.
   
 
 0.847
Dnali1
Putative inner dynein arm light chain, axonemal; May play a dynamic role in flagellar motility.
   
  
 0.815
HEATR2
Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.
   
  
 0.806
tilB
Protein tilB; Touch insensitive larva B (tilB) encodes a protein required for the assembly and/or transport to the cilium of axonemal dynein arms. tilB depletion results in deafness and male sterility because it specifically affects chordotonal neurons and spermatids, the only fly motile cilia cells. It interacts with the product of Zmynd10, which has a similar distribution and mutant phenotype.
      
 0.805
Spag1
Spag1 axonemal dynein assembly factor; Heat shock protein binding. It is involved in the biological process described with: protein targeting to mitochondrion.
   
  
 0.753
Wdr92
WD repeat domain 92; Protein domain specific binding; ubiquitin binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade.
   
 
 0.747
CG18675
Cilia- and flagella-associated protein 298; It is involved in the biological process described with: regulation of cilium movement; Belongs to the CFAP298 family.
   
  
 0.679
ATPsynepsilonL
ATP synthase, epsilon subunit-like, isoform A; Proton-transporting ATP synthase activity, rotational mechanism; ATPase activity. It is involved in the biological process described with: ATP synthesis coupled proton transport; proton transmembrane transport.
      
 0.678
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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