STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nopoNo poles (nopo) encodes a RING domain-containing E3 ubiquitin ligase that is essential for early embryogenesis. It positively regulates caspase-dependent cell death. (435 aa)    
Predicted Functional Partners:
elav
Protein elav; Required for the proper development and maintenance of neurons presumably by affecting RNA metabolism. Belongs to the RRM elav family.
      
 0.687
Lrr47
Leucine-rich repeat 47, isoform A; It is involved in the biological process described with: Ras protein signal transduction; signal transduction.
   
  
 0.686
Dcr-2
Dicer-2, isoform A; Dicer-2 (Dcr-2) encodes a member of the RNase III family of double-stranded RNA-specific endonucleases. It acts in the RNAi pathway by cutting long dsRNA into siRNAs. It helps defend flies against viral infection, particularly RNA viruses. It also processes long, partially double-stranded endogenous transcripts (hairpin RNAs) into endo-siRNAs.
      
 0.675
Act5C
Actin-5C; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
      
 0.675
Mef2
Myocyte-specific enhancer factor 2; Transcription factor that could be a key player in early mesoderm differentiation and may be required for subsequent cell fate specifications within the somatic and visceral/heart mesodermal layers. Essential for myoblast fusion and consequently muscle formation in adults. During embryonic and pupal development, binds to the enhancer of the myoblast fusion gene sing and activates its transcription. Belongs to the MEF2 family.
      
 0.651
CYLD
Cylindromatosis, isoform D; Lys63-specific deubiquitinase activity; thiol-dependent ubiquitin-specific protease activity; ubiquitinyl hydrolase activity, acting on linear ubiquitin.
    
 
 0.641
Uev1A
Ubiquitin-conjugating enzyme variant 1A (Uev1A) encodes a conserved protein that contributes to ubiquitin conjugating enzyme activity, but not catalytically, since it lacks the conserved cysteine residue essential for ubiquitin conjugation. It regulates genomic integrity, IMD pathway-mediated innate immunity, JNK-pathway mediated cell death and tumor invasion.
   
 
 0.637
RpL32
60S ribosomal protein L32; Structural constituent of ribosome. It is involved in the biological process described with: translation; cytoplasmic translation.
      
 0.605
Fancd2
Fanconi anemia complementation group D2 protein; DNA polymerase binding. It is involved in the biological process described with: synapsis; interstrand cross-link repair; intra-S DNA damage checkpoint; double-strand break repair involved in meiotic recombination; DNA repair.
   
 
 0.601
Cdc45
CDC45L (CDC45L) encodes a protein that contributes to 3'-5' DNA helicase activity of the Cdc45/Mcm2-7/GINS complex. It is involved in chromosome condensation and the regulation of the mitotic G1/S transition.
   
  
 0.559
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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