STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCHa1-RNeuropeptide CCHamide-1 receptor; Receptor for the neuropeptide CCHamide-1. Plays a role in the modulation of starvation-induced olfactory behavior where starved flies show increased responsiveness to food odorants, repellants and pheromones. (499 aa)    
Predicted Functional Partners:
CCHa2-R
Neuropeptide CCHamide-2 receptor; Receptor for the neuropeptide CCHamide-2. Belongs to the G-protein coupled receptor 1 family.
  
 
0.922
CCHa1
Neuropeptide CCHamide-1; Ligand for the CCHamide-1 receptor CCHa1-R.
      
 0.853
Proc-R
G protein-coupled receptor activity; proctolin receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; neuropeptide signaling pathway.
  
 
 0.680
Pdfr
PDF receptor; Pigment-dispersing factor receptor (Pdfr) encodes a G-Protein Coupled Receptor in the Family B class of GPCRs (Secretin Receptor-like) that can be activated by the product of Pdf. It has been implicated in regulation of circadian physiology, development of the flight motor system, and regulation of mating.
   
  
 0.620
SPR
Sex peptide receptor; Receptor for two functionally unrelated ligands; SP (A70A) for controlling reproductive behaviors and MIP for controlling sleep behavior. MIP-SPR pathway functions as a sleep homeostat which perceives the need for sleep and stabilizes it by providing a slow-acting inhibitory input to the fly arousal system that involve the pigment dispersing factor (pdf) neurons. SP-SPR is one of the multiple SP pathways that induce female post- mating behavioral responses (PMR) such as the suppression of mating receptivity and initiation of egg laying. The PMR switch is achieved [...]
  
 
 0.589
GABA-B-R1
Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways.
   
  
 0.562
FMRFaR
FMRFamide Receptor (FMRFaR) encodes a G protein coupled receptor activated by all FMRFamide peptides. It contributes to neurotransmitter release, muscle contraction, and larval escape responses to light; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.550
CG33639
IP11344p; G protein-coupled receptor activity; neuropeptide receptor activity. It is involved in the biological process described with: G protein-coupled receptor signaling pathway.
   
 
 0.536
sNPF
Short neuropeptide F precursor (sNPF) encodes a protein that binds to the product of sNPF-R and activates ERK-Dilps signaling or the PKA-CREB pathway. Its roles include the regulation of cell and organism growth, carbohydrate metabolism, lifespan, feeding behavior, locomotion, circadian rhythm, and sleep.
      
 0.497
CG3106
GH10201p; Transferase activity, transferring acyl groups other than amino-acyl groups.
      
 0.493
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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