STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
resilinPro-resilin; Plays a central role in insect flight by providing low stiffness, high strain and efficient energy storage. (620 aa)    
Predicted Functional Partners:
sli
Slit (sli) encodes a secreted glycoprotein that acts as a ligand for the Robo receptor family and co-receptors, including the products of Sdc and Dscam1. The product of sli functions as second messenger (via Abl) and receptor dependent, providing repellent (neural growth cone), attractive (trachea), and polarising (cardioblasts) cues for differentiating cells.
    
  0.900
robo1
Roundabout 1 (robo1) encodes a member of the Robo receptor family that uses the secreted glycoprotein encoded by sli as ligand and the products of Sdc and Dscam1 as co-receptors. It contributes to axon guidance and dendrite morphogenesis as well as regulating trachea and heart tube development.
     
  0.900
TwdlD
RE49895p; TweedleD (TwdlD) encodes a chitin-binding protein that is a member of the Tweedle family of cuticle proteins.
      
 0.835
GABA-B-R1
Metabotropic GABA-B receptor subtype 1 (GABA-B-R1) encodes a receptor involved in G protein-coupled receptor and gamma-aminobutyric acid signaling pathways.
      
 0.791
bt
Bent, isoform F; Bent (bt) encodes the protein Projectin, a large protein associated with myosin thick filaments in insect muscles that contributes to the stiffness of flight muscle.
    
 
 0.738
CG14964
Uncharacterized protein.
    
 
 0.697
sls
Titin; Key component in the assembly and functioning of adult and embryonic striated muscles and muscle tendons. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.
    
 
 0.689
TwdlS
RT12701p1; Structural constituent of chitin-based cuticle. It is involved in the biological process described with: body morphogenesis; chitin-based cuticle development.
      
 0.680
Cpr67B
Cuticular protein 67B; Structural constituent of cuticle; structural constituent of chitin-based larval cuticle. It is involved in the biological process described with: chitin-based cuticle development.
    
 
 0.675
obst-E
Protein obstructor-E; Chitin-binding protein that is important for the longitudinal contraction and lateral expansion of the larval cuticle during its conversion into the oval-shaped puparium case. Essential for survival to the second instar larval stage. Confers the orientated contractility and expandability of the larval cuticle by regulating the arrangement of chitin and the formation of supracellular ridges on the cuticle of third instar larvae. Essential for determining pupal body shape; required for the orientated shape change of the cuticle during metamorphosis which involves ch [...]
      
 0.671
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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