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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (385 aa)    
Predicted Functional Partners:
DNApol-delta
DNA polymerase delta catalytic subunit; As the catalytic component of the DNA polymerase delta complex, plays a crucial role in high fidelity genome replication, including lagging strand synthesis, DNA recombination and repair (By similarity). Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Required at the nucleus of rapidly dividing embryonic cells to activate genome replication during the earliest cell cycles. Likely to require the presence of accessory proteins Pol31 and Pol32 for full activity.
  
 0.997
CG2990
FI06813p; 5'-flap endonuclease activity; RNA binding. It is involved in the biological process described with: DNA replication, Okazaki fragment processing; replication fork reversal.
   
 
 0.995
DNAlig1
DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 
 0.993
PCNA
Proliferating cell nuclear antigen; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. Belongs to the PCNA family.
  
 0.991
RecQ4
RecQ4 helicase (RecQ4) encodes an important protein for genome stability and DNA metabolism. It can utilize energy from ATP hydrolysis to help the DNA strand separation and exchange, playing a critical role in replication and repair.
  
 
 0.978
mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
  
 0.977
FBgn0264326
DNA polymerase epsilon catalytic subunit 1; Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork (By similarity). Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Has a role in the G1-S transition and/or S-phase progression of the mitotic cycle and endocycle progression. Involved in DNA synthesis during DNA repair (By similarity). [...]
  
 0.976
Rrp1
Recombination repair protein 1; Plays a role in the cellular response to oxidative stress by promoting DNA repair mechanisms such as base excision repair and possibly homologous recombination repair. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Likely to initiate repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydrox [...]
  
 0.974
PCNA2
Proliferating cell nuclear antigen 2; Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. May function independently of PCNA during DNA repair.
  
 
 0.973
Mcm5
DNA replication licensing factor Mcm5; Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
  
 0.962
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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