STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Sod2Superoxide dismutase 2 (Mn) (Sod2) encodes an enzyme that detoxifies superoxide radicals in mitochondria. The loss of Sod2 generates endogenous oxidative stress that results in reduced activity of critical mitochondrial enzymes, hypersensitivity to oxidative stress and neonatal lethality. A muscle restricted p38Kinase-Mef2-Sod2 signaling module influences life span and stress. (217 aa)    
Predicted Functional Partners:
Sod1
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
   
 0.993
mRpS29
Mitochondrial ribosomal protein S29; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; apoptotic process; translation.
   
 
 0.982
Sod3
Superoxide dismutase 3 (Sod3) encodes an extra-cellular Cu Zn superoxide dismutase that can be produced as secreted and membrane bound forms. It converts oxygen free radicals to hydrogen peroxide and is involved in free radical defense and redox balance; Belongs to the Cu-Zn superoxide dismutase family.
   
 0.981
CG5948
Uncharacterized protein, isoform A; Superoxide dismutase activity; copper ion binding. It is involved in the biological process described with: removal of superoxide radicals.
   
 0.980
mRpL15
Mitochondrial ribosomal protein L15; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
  
 
 0.975
mRpL13
39S ribosomal protein L13, mitochondrial; mRNA binding; structural constituent of ribosome. It is involved in the biological process described with: negative regulation of translation; mitochondrial translation; translation; Belongs to the universal ribosomal protein uL13 family.
  
 
 0.973
mRpL3
Mitochondrial ribosomal protein L3; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation; translation.
  
 
 0.971
mRpL47
Mitochondrial ribosomal protein L47; Structural constituent of ribosome. It is involved in the biological process described with: mitochondrial translation.
   
 
 0.970
mRpL46
Mitochondrial ribosomal protein L46; Structural constituent of ribosome; hydrolase activity. It is involved in the biological process described with: mitochondrial translation.
   
 
 0.967
mRpL17
Mitochondrial ribosomal protein L17, isoform A; Structural constituent of ribosome. It is involved in the biological process described with: translation; mitochondrial translation.
   
 
 0.965
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (40%) [HD]