STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Idgf6Imaginal disc growth factor 6 (Idgf6) is one of six genes in the IDGF family, which evolved from chitinases that lost their enzymatic activity. Idgf6 encodes a secreted protein that is highly expressed in larval fat body and adult head. Idgf6 product is involved in molting and egg chamber tube morphogenesis. (452 aa)    
Predicted Functional Partners:
CG15202
Uncharacterized protein, isoform A.
      
 0.676
obst-A
Obstructor-A, isoform A; obstructor-A (obst-A) encodes a protein that forms a core complex with chitin and the chitin modifying proteins encoded by serp and knk. This complex is required for assembly, maturation and preservation of the chitinous cuticles at the end of embryogenesis and probably throughout larval development.
      
 0.609
JhI-26
Juvenile hormone-inducible protein 26 (JhI-26) encodes a sperm protein. Overexpression of JhI-26 in males causes upregulation of the male accessory gland protein (Acp) gene CG10433, higher embryonic lethality and reduction of receptivity to remating in mated females.
   
 
 0.554
Idgf2
Chitinase-like protein Idgf2; Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex; Belongs to the glycosyl hydrolase 18 family. IDGF subfamily.
  
  
0.523
Aldh
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol.
   
  
 0.510
serp
Serpentine, isoform B; Serpentine (serp) encodes a putative chitin deacetylase. It is expressed by the epidermal and tracheal cells and is secreted into the apical extracellular space. Its activity maintains the strength of cuticles and restricts tracheal tube length.
      
 0.491
verm
Vermiform, isoform I; Vermiform (verm) encodes a chitin deacetylase-like protein that is secreted by tracheal cells and accumulates in the embryonic tracheal lumen. Its functions include cuticle development and tracheal tube size control.
      
 0.491
ng3
Protein new-glue 3.
   
  
 0.451
knk
Knickkopf (knk) encodes a GPI-anchorded protein, needed for chitin organisation in the cuticle and the tracheal system (tracheal cuticle, tube diameter regulation & gas filling).
      
 0.448
Cht11
Chitinase activity; chitin binding. It is involved in the biological process described with: chitin catabolic process; carbohydrate metabolic process; Belongs to the glycosyl hydrolase 18 family.
  
   
0.435
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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