STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG7747LD20635p; Ubiquitin-protein transferase activity; ubiquitin-ubiquitin ligase activity; peptidyl-prolyl cis-trans isomerase activity. It is involved in the biological process described with: protein peptidyl-prolyl isomerization; mRNA splicing, via spliceosome; protein folding; protein polyubiquitination. (517 aa)    
Predicted Functional Partners:
l(2)37Cb
Lethal (2) 37Cb; RNA binding; RNA helicase activity. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.935
CG6015
LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.933
CG10907
RE08109p; Peptidyl-prolyl cis-trans isomerase activity. It is involved in the biological process described with: protein peptidyl-prolyl isomerization; protein folding; mRNA splicing, via spliceosome.
  
0.927
mdlc
CG4973 protein; Midlife crisis (mdlc) encodes a nuclear protein that is required for maintaining neuronal differentiation.
   
 0.921
Srrm1
FI04407p; SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl.
   
 0.914
ncm
Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.
   
 0.914
CG10324
FI23980p1.
   
  0.914
Mfap1
Microfibrillar-associated protein 1; Required for pre-mRNA splicing.
   
  0.913
l(1)G0007
Lethal (1) G0007 (l(1)G0007) encodes a protein involved in alternative mRNA splicing regulation.
   
 0.907
Cwc25
LD47748p; It is involved in the biological process described with: mRNA splicing, via spliceosome.
   
 0.874
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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