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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cluClueless (clu) encodes a cytoplasmic ribonucleoprotein that is required for mitochondrial function. It functions in part with protein complexes at the outer mitochondrial membrane, such as the ribosome, the translocase complex TOM and the mitophagy proteins encoded by park and Pink1. Loss of clu causes mitochondrial oxidative damage, decreased ATP and lethality. (1448 aa)    
Predicted Functional Partners:
CG9393
Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family.
     
 0.951
CG5662
AT01806p; It is involved in the biological process described with: protein targeting to mitochondrion.
     
 0.920
tomboy40
Mitochondrial import receptor subunit TOM40 homolog 2; Channel-forming protein essential for import of protein precursors into mitochondria; Belongs to the Tom40 family.
   
 
 0.853
Tom7
Translocase of outer membrane 7 (Tom7) encodes a putative mitochondrial protein that may act as a channel component of the TOM complex based on orthology with the human gene TOMM7.
     
 0.851
Tom70
Translocase of outer membrane 70 (Tom70) encodes a mitochondrial protein that may act as a receptor of the TOM complex based on orthology. TOM complex is involved in protein import into mitochondria. The product of Tom70 modulates cell death induced by the expression of the mouse Bax protein.
   
 
 0.838
tomboy20
GEO10511p1; P-P-bond-hydrolysis-driven protein transmembrane transporter activity; mitochondrion targeting sequence binding. It is involved in the biological process described with: protein targeting to mitochondrion; protein import into mitochondrial matrix; mitochondrial outer membrane translocase complex assembly; tRNA import into mitochondrion.
     
 0.820
mge
Mitochondrial import protein; Maggie (mge) encodes a protein predicted to act as a receptor of the TOM (translocase of outer membrane) complex, which is involved in protein import into mitochondria. The product of mge modulates cell death induced by the expression of the mouse Bax protein.
   
 
  0.751
eIF3b
Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
   
 
 0.745
Tom20
Translocase of outer membrane 20, isoform A; Mitochondrion targeting sequence binding; P-P-bond-hydrolysis-driven protein transmembrane transporter activity. It is involved in the biological process described with: protein targeting to mitochondrion; tRNA import into mitochondrion; mitochondrial outer membrane translocase complex assembly; protein import into mitochondrial matrix.
    
 0.736
Tom40
Mitochondrial import receptor subunit TOM40 homolog 1; Translocase of outer membrane 40 (Tom40) encodes a protein predicted to be a channel component of the TOM complex, which is involved in protein import into mitochondria. It is predicted to be involved in the cellular response to hypoxia.
   
 
 0.704
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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