STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fusRNA-binding protein fusilli; mRNA splicing factor that regulates alternative splicing od specific genes. Has a maternal role in embryonic dorsal-ventral patterning; such role is probably indirect and due to its function as mRNA splicing factor regulator. (967 aa)    
Predicted Functional Partners:
TBPH
TAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping.
    
 
 0.851
Sod1
Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.
      
 0.609
Hrb98DE
Heterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate.
    
 
 0.545
cpo
Couch potato (cpo) is most strongly expressed in nuclei of the central and peripheral nervous systems and the ring gland, where its product may regulate gene transcription to control complex neurological and neuroendocrine functions. It is required for normal synaptic transmission, climate adaptation, olfaction, diapause and behavioral responses.
    
 
 0.542
CG34133
RE64336p; Rab GTPase binding.
      
 0.536
Glos
Gaulos, isoform A.
      
 0.523
CG5522
Uncharacterized protein, isoform A; Ral guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: regulation of Ral protein signal transduction.
      
 0.504
Tnpo
Transportin, isoform A; Transportin (Tnpo) encodes a protein involved in Hh signalling regulation by mediating the import of the transcription factor encoded by ci into the nucleus.
      
 0.491
CG8219
Importin N-terminal domain-containing protein; Ran GTPase binding; nuclear localization sequence binding; nuclear import signal receptor activity. It is involved in the biological process described with: protein import into nucleus.
      
 0.491
CG11737
RE12402p; It is involved in the biological process described with: peroxisome organization.
      
 0.491
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.