node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ItgaPS4 | ItgaPS5 | FBpp0086503 | FBpp0423081 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | 0.910 |
ItgaPS4 | Itgbn | FBpp0086503 | FBpp0080990 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | 0.977 |
ItgaPS4 | LanA | FBpp0086503 | FBpp0076722 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Laminin subunit alpha; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth. | 0.401 |
ItgaPS4 | if | FBpp0086503 | FBpp0290568 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. | 0.909 |
ItgaPS4 | mew | FBpp0086503 | FBpp0309167 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS1 heavy chain; Multiple edematous wings (mew) encodes one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for the extracellular matrix protein laminin. It is required in numerous tissues for cell migration, adhesion between cell layers, and cell differentiation. | 0.932 |
ItgaPS4 | mys | FBpp0086503 | FBpp0309123 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] | 0.987 |
ItgaPS4 | scb | FBpp0086503 | FBpp0086501 | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS3 heavy chain; Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic [...] | 0.907 |
ItgaPS5 | ItgaPS4 | FBpp0423081 | FBpp0086503 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | 0.910 |
ItgaPS5 | Itgbn | FBpp0423081 | FBpp0080990 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | 0.985 |
ItgaPS5 | LanA | FBpp0423081 | FBpp0076722 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Laminin subunit alpha; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth. | 0.440 |
ItgaPS5 | if | FBpp0423081 | FBpp0290568 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. | 0.909 |
ItgaPS5 | mew | FBpp0423081 | FBpp0309167 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS1 heavy chain; Multiple edematous wings (mew) encodes one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for the extracellular matrix protein laminin. It is required in numerous tissues for cell migration, adhesion between cell layers, and cell differentiation. | 0.938 |
ItgaPS5 | mys | FBpp0423081 | FBpp0309123 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin beta-PS; Integrin alpha-PS1/beta-PS is a receptor for laminin. Integrin alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/talin and Itgbn does not. Required for rhea/talin correct cellular localization in the midgut. Required for m [...] | 0.987 |
ItgaPS5 | scb | FBpp0423081 | FBpp0086501 | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | Integrin alpha-PS3 heavy chain; Integrin alpha-PS3/beta-PS is a receptor for laminin. Also binds to wb. Important during embryogenesis for the development of the trachea, dorsal vessel and salivary gland, as well as for dorsal closure. Required for short-term memory processes. Minor involvement in the establishment of the oocyte anterior-posterior length. Plays a role in timely border cell migration during oogenesis, probably mediated by JNK signaling. Integrin alpha-PS3/Itgbn is required for effective phagocytosis of apoptotic cells during embryonic development and for the phagocytic [...] | 0.906 |
Itgbn | ItgaPS4 | FBpp0080990 | FBpp0086503 | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | Integrin alpha-PS4; Possible role in cell adhesion. Minor involvement in the establishment of the oocyte anterior-posterior length. | 0.977 |
Itgbn | ItgaPS5 | FBpp0080990 | FBpp0423081 | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | Integrin alpha-PS5; Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. | 0.985 |
Itgbn | LanA | FBpp0080990 | FBpp0076722 | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | Laminin subunit alpha; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Activates presynaptic signaling involving integrin alpha-PS3/beta-nu and Fak to suppress neuromuscular junction (NMJ) growth during larval development and during low crawling activity, but not during higher-crawling conditions. Mediates, together with integrin alpha-PS3/beta-nu, glutamate receptor-modulated NMJ growth. | 0.954 |
Itgbn | Pax | FBpp0080990 | FBpp0099871 | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | Paxillin, isoform F; Paxillin (Pax) encodes an adaptor protein that is generally associated with integrins. It is not required for most integrin-mediated adhesion or migration events, but is required for viability beyond pupal stages. It controls the size of some muscles by regulating the rate of cell fusion. | 0.852 |
Itgbn | Vinc | FBpp0080990 | FBpp0309623 | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | Vinculin (Vinc) encodes a key mechanoeffector of cell-cell and cell-extracellular matrix adhesion. It binds to the products of rhea and alpha-Cat, when they are stretched by force, and links them to actin. Vinc mutant flies are viable and fertile although mild defects have been documented in muscle attachment and heart function; Belongs to the vinculin/alpha-catenin family. | 0.866 |
Itgbn | if | FBpp0080990 | FBpp0290568 | Integrin beta-nu; Contributes to endodermal integrity and adhesion between the midgut epithelium and the surrounding visceral muscle. Essential for migration of the primordial midgut cells and for maintaining, but not establishing, cell polarity in the midgut epithelium. Can only partially compensate for the loss of beta-PS integrin during primordial midgut cell migration. The two beta subunits mediate midgut migration by distinct mechanisms: beta-PS requires rhea/Talin and beta-nu does not. Integrin alpha-PS3/beta-nu is required for effective phagocytosis of apoptotic cells during emb [...] | Integrin alpha-PS2 heavy chain; Inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. | 0.943 |