node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CG10694 | CG17493 | FBpp0083927 | FBpp0304878 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | 0.722 |
CG10694 | CG42750 | FBpp0083927 | FBpp0292372 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | Dipeptidase; Beta-lactamase activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. | 0.471 |
CG10694 | Ercc1 | FBpp0083927 | FBpp0086578 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | Nucleotide excision repair protein ERCC1; Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination. | 0.525 |
CG10694 | Rad23 | FBpp0083927 | FBpp0305835 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. | 0.923 |
CG10694 | Tfb1 | FBpp0083927 | FBpp0086678 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.608 |
CG10694 | Xpc | FBpp0083927 | FBpp0086505 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | DNA repair protein complementing XP-C cells homolog; Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity). | 0.966 |
CG10694 | Xpd | FBpp0083927 | FBpp0071503 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. | 0.706 |
CG10694 | hay | FBpp0083927 | FBpp0075982 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.709 |
CG10694 | mei-9 | FBpp0083927 | FBpp0070624 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | DNA repair endonuclease XPF; Implicated in recombination events during meiosis, mostly in meiotic exchange. May directly resolve Holliday junctions within recombination intermediates leading to DNA exchange. Also required for the repair of mismatches within meiotic heteroduplex DNA and for nucleotide excision repair. | 0.441 |
CG10694 | mus201 | FBpp0083927 | FBpp0311946 | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | Mutagen-sensitive 201 (mus201) encodes a protein involved in UV-damage excision repair. | 0.440 |
CG17493 | CG10694 | FBpp0304878 | FBpp0083927 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | 0.722 |
CG17493 | Rad23 | FBpp0304878 | FBpp0305835 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. | 0.761 |
CG17493 | Tfb1 | FBpp0304878 | FBpp0086678 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.552 |
CG17493 | Xpc | FBpp0304878 | FBpp0086505 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | DNA repair protein complementing XP-C cells homolog; Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity). | 0.978 |
CG17493 | Xpd | FBpp0304878 | FBpp0071503 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | Xeroderma pigmentosum D (Xpd) encodes a DNA helicase that is a subunit of the basal transcription and DNA repair factor TFIIH. | 0.593 |
CG17493 | hay | FBpp0304878 | FBpp0075982 | Uncharacterized protein, isoform B; Calcium ion binding. It is involved in the biological process described with: mitotic cell cycle; centriole replication. | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of haywire/XPB/ERCC3, but not its helicase activity, is req [...] | 0.601 |
CG42750 | CG10694 | FBpp0292372 | FBpp0083927 | Dipeptidase; Beta-lactamase activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | 0.471 |
CG42750 | Rad23 | FBpp0292372 | FBpp0305835 | Dipeptidase; Beta-lactamase activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. | DNA repair protein Rad23; Rad23 (Rad23) encodes an evolutionarily conserved member of the proteasome-associated proteins. It acts as a shuttle -or bridge- protein helping ubiquitinated proteins to interact with the proteasome, which in turn regulates their turnover. | 0.471 |
CG42750 | Xpc | FBpp0292372 | FBpp0086505 | Dipeptidase; Beta-lactamase activity; dipeptidase activity; dipeptidyl-peptidase activity; metalloexopeptidase activity. It is involved in the biological process described with: proteolysis; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. | DNA repair protein complementing XP-C cells homolog; Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes (By similarity). | 0.899 |
Ercc1 | CG10694 | FBpp0086578 | FBpp0083927 | Nucleotide excision repair protein ERCC1; Ercc1 (Ercc1) encodes the non-catalytic partner of the nuclease encoded by mei-9 that cuts structures formed during DNA repair. The mei-9-Ercc1 heterodimer interacts with the product of mus312 to make meiotic crossovers. The functions of the product of Ercc1 include repair of UV-induced DNA damage, repair of base adducts, a backup pathway for mismatch repair and meiotic recombination. | AT15685p; Ubiquitin binding; polyubiquitin modification-dependent protein binding; damaged DNA binding; proteasome binding. It is involved in the biological process described with: nucleotide-excision repair; proteasome-mediated ubiquitin-dependent protein catabolic process. | 0.525 |