STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG10257RH51312p; It is involved in the biological process described with: negative regulation of apoptotic process; neuron projection morphogenesis (228 aa)    
Predicted Functional Partners:
CG2987
Alpha-catenin related, isoform A; Actin filament binding; actin binding. It is involved in the biological process described with: cell adhesion
    
   0.605
CG12343
Pre-mRNA-splicing factor Syf2; May be involved in pre-mRNA splicing
   
  
 0.535
spir
Protein spire; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton
      
 0.483
Nmt
Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins
      
 0.453
Zfrp8
Zinc finger protein RP-8 (Zfrp8) is a highly conserved protein essential for stem cell maintenance and fast proliferating cells such as cancer cells. Zfrp8 functions in the formation of mRNA ribonucleoprotein (mRNP) complexes. Zfrp8 may regulate the binding of specific mRNPs to the small ribosomal subunit, ultimately controlling their cytoplasmic localization and translation
   
  
 0.433
Rab3-GEF
MAP kinase-activating death domain protein; Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase- mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms
      
 0.410
CG2964
Pyruvate kinase; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process
      
 0.406
PyK
Pyruvate kinase; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process; myoblast fusion; somatic muscle development; phosphorylation
      
 0.406
CG7069
Pyruvate kinase; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: glycolytic process
      
 0.406
CG7362
CG7362; Potassium ion binding; magnesium ion binding; pyruvate kinase activity. It is involved in the biological process described with: phagocytosis; glycolytic process
      
 0.406
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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