STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Su(var)2-HP2Su(Var)2-HP2, isoform A; Su(var)2-HP2 (Su(var)2-HP2) encodes a chromosomal protein that interacts with the product of Su(var)205 and is found most closely associated with centromeric heterochromatin, telomeres and the fourth chromosome. Lack of Su(var)2-HP2 can cause mitotic abnormalities and suppress position-effect variegation. (3257 aa)    
Predicted Functional Partners:
Su(var)205
Heterochromatin protein 1; Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.
    
 
 0.881
ADD1
ADD domain-containing protein 1 (ADD1) encodes a strong Heterochromatin Protein 1 interactor that interacts with methylated H3K9 silencing marks in heterochromatin.
   
 
 0.802
vig2
Vig2, isoform B; Vig2 (vig2) encodes a protein involved in heterochromatin organization, histone H3-K9 methylation and chromatin silencing regulation.
    
 
 0.758
CG13085
Uncharacterized protein, isoform A; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process.
      
 0.675
CG11970
BcDNA.LD23876; Protease binding.
   
  
 0.657
CG32085
FI04525p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process.
      
 0.628
CG10949
GH22016p; It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
      
 0.627
HP1b
Heterochromatin Protein 1b (HP1b) encodes a chromatin binding protein that negatively regulates transcription and heterochromatin formation.
    
 
 0.611
vig
Vasa intronic gene (vig) encodes a protein involved in RNA interference and heterochromatin organization.
    
 
 0.585
CG42232
Uncharacterized protein.
   
 
 0.558
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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