STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GstE14Glutathione S-transferase E14; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Essential for ecdysteroid biosynthesis. May be involved in detoxification. (232 aa)    
Predicted Functional Partners:
GluProRS
Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
   
 
 0.875
nvd
Rieske-domain protein Neverland; Neverland (nvd) encodes an evolutionarily conserved oxygenase-like protein that is required for the biosynthesis pathway of ecdysone. It converts cholesterol to 7-dehydrocholesterol.
   
  
 0.841
dib
Disembodied (dib) encodes a cytochrome P450 involved in ecdysteroid biosynthesis. It shows a mitochondrial localization and catalyzes the addition of a hydroxyl group to the 22 carbon of the cholesterol side chain. dib mutants fail to undergo head involution, dorsal closure and to secrete cuticle.
   
  
 0.811
sro
Shroud (sro) encodes a short-chain dehydrogenase/reductase that is essential for ecdysone biosynthesis. It is hypothesized to work in the conversion of 7-dehydrocholesterol to 5beta-ketodiol; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.803
GstO1
Glutathione S-transferase omega class; Glutathione S transferase O1 (GstO1) encodes a transferase involved in glutathione metabolism; Belongs to the GST superfamily.
   
 
 0.785
GstE8
Glutathione transferase activity. It is involved in the biological process described with: glutathione metabolic process.
  
  
0.749
GstE5
Glutathione transferase activity. It is involved in the biological process described with: glutathione metabolic process.
  
  
0.731
GstE7
Glutathione S transferase E7 (GstE7) encodes a cytosolic enzyme that functions in detoxication. It has high catalytic activity with various isothiocyanates and the toxic environmental pollutants 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT).
  
  
0.725
GstT2
Glutathione S transferase T2 (GstT2) encodes an enzyme involved in glutathione metabolic processes; Belongs to the GST superfamily.
  
  
0.721
GstT1
Glutathione S transferase T1 (GstT1) encodes an enzyme involved in glutathione metabolic processes; Belongs to the GST superfamily.
  
  
0.719
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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