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TppII protein (fruit fly) - STRING interaction network
"TppII" - Tripeptidyl-peptidase 2 in Drosophila melanogaster
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
TppIITripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala- polypeptide, Val-Leu-Lys-polypeptide only at high concentration. Does not cleave Ala-Phe-Pro-polypeptide nor Pro-Leu-Gly- polypeptide; Belongs to the peptidase S8 family (1441 aa)    
Predicted Functional Partners:
DppIII
Dipeptidyl peptidase 3; Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues; Belongs to the peptidase M49 family (786 aa)
     
   
  0.880
CG9578
annotation not available (272 aa)
       
      0.729
Psa
Puromycin sensitive aminopeptidase, isoform C; Metallopeptidase activity; zinc ion binding; aminopeptidase activity. It is involved in the biological process described with- proteolysis (1075 aa)
   
   
  0.672
Ppt1
Palmitoyl-protein thioesterase 1 is a lysosomal enzyme that removes palmitoyl groups from particular target proteins during protein degradation within the lysosomal compartment. Palmitoylation is critical for the cellular localization and modulation of many signaling proteins (314 aa)
         
  0.666
CG1827
Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase CG1827; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins; Belongs to the Ntn-hydrolase family (377 aa)
           
  0.655
CG4572
Serine-type carboxypeptidase activity. It is involved in the biological process described with- proteolysis; dsRNA transport; Belongs to the peptidase S10 family (482 aa)
     
 
  0.646
Atg5
Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity) (269 aa)
           
  0.570
botv
Exostosin-3; Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. Plays a central role in diffusion of morphogens hedgehog (hh), wingless (wg) and Decapentaplegic (dpp) via its role in heparan sulfate proteoglycans (HSPGs) biosynthesis, HSPGs being required for movement of Hh, Dpp and wg morphogens (972 aa)
 
 
        0.531
Cas
Exportin-2; Export receptor for importin alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity) (975 aa)
     
      0.496
svr
Carboxypeptidase D; Required for the proper melanization and sclerotization of the cuticle; Belongs to the peptidase M14 family (1439 aa)
     
   
  0.494
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Drosophila melanogaster, fruit fly
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