STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TppIITripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Efficiently cleaves Ala-Ala-Ala-polypeptide and Pro-Pro-Ala-polypeptide, Val-Leu-Lys- polypeptide only at high concentration. Does not cleave Ala-Phe-Pro- polypeptide nor Pro-Leu-Gly-polypeptide; Belongs to the peptidase S8 family. (1441 aa)    
Predicted Functional Partners:
CG1440
Uncharacterized protein, isoform D; Cysteine-type peptidase activity; cysteine-type endopeptidase activity. It is involved in the biological process described with: homocysteine catabolic process; response to toxic substance; proteolysis.
   
 
 0.767
SP1029
Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: proteolysis; peptide catabolic process.
  
 
 0.735
CG2111
Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis.
  
 
 0.729
CG11951
Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis.
  
 
 0.729
CG9806
Metalloaminopeptidase activity; peptide binding; zinc ion binding. It is involved in the biological process described with: multicellular organism reproduction; peptide catabolic process; proteolysis.
  
 
 0.728
CG3502
Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis.
  
 
 0.728
CG31445
Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis.
  
 
 0.728
CG31343
Aminopeptidase; Zinc ion binding; peptide binding; metalloaminopeptidase activity. It is involved in the biological process described with: peptide catabolic process; proteolysis.
  
 
 0.726
CG31233
Metalloaminopeptidase activity; zinc ion binding; peptide binding. It is involved in the biological process described with: peptide catabolic process; proteolysis.
  
 
 0.723
CG6071
Aminopeptidase; Peptide binding; zinc ion binding; metalloaminopeptidase activity. It is involved in the biological process described with: multicellular organism reproduction; proteolysis; peptide catabolic process.
  
 
 0.687
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (32%) [HD]