node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Tgi | sd | FBpp0075553 | FBpp0301994 | Tondu-domain-containing Growth Inhibitor (Tgi) encodes a protein that interacts with both components of the sd-yki transcriptional complex to inhibit its activity and thus restrict tissue growth. | Scalloped, isoform Q; Scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification. | 0.989 |
Tgi | vg | FBpp0075553 | FBpp0086898 | Tondu-domain-containing Growth Inhibitor (Tgi) encodes a protein that interacts with both components of the sd-yki transcriptional complex to inhibit its activity and thus restrict tissue growth. | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] | 0.546 |
Tgi | yki | FBpp0075553 | FBpp0402906 | Tondu-domain-containing Growth Inhibitor (Tgi) encodes a protein that interacts with both components of the sd-yki transcriptional complex to inhibit its activity and thus restrict tissue growth. | Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...] | 0.962 |
ap | vg | FBpp0085394 | FBpp0086898 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] | 0.657 |
ap | wg | FBpp0085394 | FBpp0079060 | Apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding. | Protein wingless; Binds as a ligand to a family of frizzled seven-transmembrane receptors and acts through a cascade of genes on the nucleus. Segment polarity protein. May be a growth factor. Acts on neighboring cells to regulate at least one gene, the homeobox segmentation gene engrailed. Wg signal represses arm phosphorylation. Wg signaling operates by inactivating the sgg repression of engrailed autoactivation. Wg and Wnt2 have a role in the developing trachea and together are responsible for all dorsal trunk formation. Wg also acts in the developing epidermis. Acts as a morphogen, [...] | 0.421 |
brm | lab | FBpp0303193 | FBpp0081194 | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | Homeotic protein labial; Labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut. | 0.448 |
brm | pb | FBpp0303193 | FBpp0088333 | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps. | 0.461 |
brm | ph-d | FBpp0303193 | FBpp0070417 | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. | 0.543 |
brm | sd | FBpp0303193 | FBpp0301994 | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | Scalloped, isoform Q; Scalloped (sd) encodes a DNA binding protein of the TEAD class. It requires co-factor proteins ,such as the products of vg and yki, to act as a transcription factor, and is modified by Hippo and Wingless signalling. It is involved in wing and neuronal specification. | 0.518 |
brm | vg | FBpp0303193 | FBpp0086898 | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] | 0.491 |
brm | yki | FBpp0303193 | FBpp0402906 | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | Transcriptional coactivator yorkie; Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/ [...] | 0.674 |
lab | brm | FBpp0081194 | FBpp0303193 | Homeotic protein labial; Labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut. | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | 0.448 |
lab | pb | FBpp0081194 | FBpp0088333 | Homeotic protein labial; Labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut. | Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps. | 0.532 |
lab | ph-d | FBpp0081194 | FBpp0070417 | Homeotic protein labial; Labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut. | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. | 0.607 |
lab | vg | FBpp0081194 | FBpp0086898 | Homeotic protein labial; Labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut. | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] | 0.550 |
pb | brm | FBpp0088333 | FBpp0303193 | Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps. | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | 0.461 |
pb | lab | FBpp0088333 | FBpp0081194 | Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps. | Homeotic protein labial; Labial (lab) encodes the anterio-most expressed member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. The product of lab specifies the identity of the intercalary segment and also functions in the development of copper cells in the midgut. | 0.532 |
pb | ph-d | FBpp0088333 | FBpp0070417 | Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps. | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. | 0.611 |
pb | vg | FBpp0088333 | FBpp0086898 | Homeotic protein proboscipedia; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls development of mouthparts, and labial and maxillary palps. | Protein vestigial; Involved in determining which thoracic imaginal disk cells will form wings and halteres, perhaps by interacting with other nuclear regulatory proteins. When in combination with scalloped (sd), it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to sd switches the DNA target selectivity of sd. Required and sufficient for cell proliferation at the dorsal/ventral (D/V) boundary of the wing imaginal disk. Also required for cell proliferation in the wing imaginal disk, mediated via activation of E2f. By interacting with Dhfr [...] | 0.563 |
ph-d | brm | FBpp0070417 | FBpp0303193 | Polyhomeotic distal (ph-d) encodes a stoichiometric subunit of the Polycomb repressive complex 1. The complex silences a variety of genes involved in developmental patterning, regulation of cell proliferation, differentiation and polarity. Together with its paralog ph-p, ph-d functions as a tumor suppressor gene. | ATP-dependent helicase brm; Transcriptional regulator. Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters. Can counteract the repressive effect of Polycomb protein. ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. This complex can both serve as a transcriptional coactivator or corepressor, depending on the context. In type II neuroblast li [...] | 0.543 |