STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
sugZinc finger protein GLIS2 homolog; Sugarbabe (sug) encodes a transcription factor that regulates the expression of insulin-like peptides and genes involved in lipid and carbohydrate metabolism. It is a direct target of the sugar sensor encoded by Mondo and its expression is also promoted by the product of daw; Belongs to the GLI C2H2-type zinc-finger protein family. (384 aa)    
Predicted Functional Partners:
CG15923
Uncharacterized protein, isoform C; It is involved in the biological process described with: cilium assembly; negative regulation of centrosome duplication.
      
 0.556
Xrp1
Xrp1, isoform A; Xrp1 (Xrp1) encodes an AT-Hook, bZip DNA binding protein involved in genome stability maintenance. It heterodimerizes with the product of Irbp18 to bind to P element sequences contributing to transposition. It is induced by p53 following X-irradiation and by mutations or knockdown of caz or ribosomal protein (Rp) encoding genes. It contributes to the slow growth of Minute (Rp+/-) mutants cell-autonomously by inhibiting translation and non-autonomously through regulation of the product of Ilp8.
   
 
 0.503
crc
Cryptocephal, isoform A; Cryptocephal (crc) encodes a protein that belongs to a member of the CREB/ATF family of basic-leucine zipper transcription factors. It serves as an coactivator of the product EcR of to promote expression the molting peptide hormone encoded by ETH. It also acts as an unfolded protein response transcription factor to regulate glycolytic genes in response to ER stress.
    
 
 0.471
Lsd-1
Lipid storage droplet-1 (Lsd-1) encodes a protein associated with lipid droplets. It protects lipid droplets from lipase mediated remobilization and facilitates lipolysis by serving as an anchoring point for lipases such as the one encoded by Hsl. It is involved in lipid storage amount regulation and energy homeostasis in concert with the product of Lsd-2.
   
 
 0.457
olf413
MOXD1 homolog 2; Dopamine beta-monooxygenase activity; copper ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. It is involved in the biological process described with: dopamine catabolic process; oxidation-reduction process; octopamine biosynthetic process; norepinephrine biosynthetic process.
      
 0.447
BBS1
Bardet-Biedl syndrome 1; Patched binding; smoothened binding. It is involved in the biological process described with: protein localization to cilium; non-motile cilium assembly; cilium assembly.
   
 
 0.444
Zpr1
LD37736p; Zpr1 (Zpr1) encodes a protein that functions downstream of the EGFR and other tyrosine kinase receptors. It also contributes to the assembly of spliceosome snRNPs. In the developing tracheal system it is required for terminal cell lumen formation.
      
 0.441
alpha-Est3
Alpha-Esterase-3, isoform A; Carboxylic ester hydrolase activity.
    
 
 0.441
pins
Partner of inscuteable (pins) encodes a GDP-dissociation inhibitor involved in asymmetric cell division and mitotic spindle orientation.
    
 
 0.438
CG9117
FI02812p.
      
 0.424
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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