node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amph | CG8176 | FBpp0086941 | FBpp0112119 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | 0.939 |
Amph | Chc | FBpp0086941 | FBpp0089398 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | 0.982 |
Amph | Cip4 | FBpp0086941 | FBpp0112051 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics. | 0.876 |
Amph | Dap160 | FBpp0086941 | FBpp0297159 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.901 |
Amph | Drp1 | FBpp0086941 | FBpp0307166 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.878 |
Amph | Synj | FBpp0086941 | FBpp0300559 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. | 0.967 |
Amph | Vps29 | FBpp0086941 | FBpp0077625 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. | 0.877 |
Amph | WASp | FBpp0086941 | FBpp0084721 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | WASp, isoform A; WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis. | 0.972 |
Amph | Whamy | FBpp0086941 | FBpp0110086 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | WHAMM and JMY related (Whamy) encodes a Rac GTPase binding protein that promotes fast actin filament elongation. It is involved in cell migration, microtubule bundle formation and myoblast fusion. | 0.873 |
Amph | shi | FBpp0086941 | FBpp0305866 | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.998 |
CG8176 | Amph | FBpp0112119 | FBpp0086941 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | 0.939 |
CG8176 | Chc | FBpp0112119 | FBpp0089398 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | 0.889 |
CG8176 | Cip4 | FBpp0112119 | FBpp0112051 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics. | 0.931 |
CG8176 | Dap160 | FBpp0112119 | FBpp0297159 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Dynamin associated protein 160 (Dap160) encodes an adaptor protein that contributes to endocytosis. It regulates the Notch pathway and mediates the asymmetric accumulation of a number or proteins, including the product of aPKC during neuroblast division. | 0.986 |
CG8176 | Drp1 | FBpp0112119 | FBpp0307166 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Dynamin related protein 1 (Drp1) encodes a dynamin-like GTPase that mediates mitochondrial fission through a process that involves translocation to the mitochondrial outer membrane and oligomerization. It is required for normal neuronal development and maintenance of postmitotic neuronal function and viability; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.402 |
CG8176 | Synj | FBpp0112119 | FBpp0300559 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Synaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. | 0.595 |
CG8176 | WASp | FBpp0112119 | FBpp0084721 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | WASp, isoform A; WASp (WASp) encodes the homolog of the conserved Wiskott-Aldrich Syndrome family of nucleation promoting factors. It enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays. It contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis. | 0.724 |
CG8176 | Whamy | FBpp0112119 | FBpp0110086 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | WHAMM and JMY related (Whamy) encodes a Rac GTPase binding protein that promotes fast actin filament elongation. It is involved in cell migration, microtubule bundle formation and myoblast fusion. | 0.690 |
CG8176 | shi | FBpp0112119 | FBpp0305866 | AT02057p; Phospholipid binding; cytoskeletal protein binding; AP-2 adaptor complex binding. It is involved in the biological process described with: clathrin-dependent endocytosis; clathrin coat assembly. | Dynamin; Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.669 |
Chc | Amph | FBpp0089398 | FBpp0086941 | Clathrin heavy chain (Chc) encodes a protein that forms part of the clathrin complex, which is the major component of coated vesicles. | Amphiphysin, isoform A; Amphiphysin (Amph) encodes a BAR and SH3 domain containing protein that regulates muscle transverse tubule formation. It exhibits post-synaptic localization at the neuromuscular junction and its mutants show locomotion defects. | 0.982 |