STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG33672GEO02273p1; Iron-sulfur cluster binding. It is involved in the biological process described with: cellular iron ion homeostasis; [2Fe-2S] cluster assembly. (86 aa)    
Predicted Functional Partners:
CG6523
LD40224p; Protein disulfide oxidoreductase activity; electron transfer activity. It is involved in the biological process described with: cellular iron ion homeostasis; cell redox homeostasis.
  
 
 0.995
CG14407
Glutaredoxin; Electron transfer activity; protein disulfide oxidoreductase activity. It is involved in the biological process described with: cell redox homeostasis; Belongs to the glutaredoxin family. Monothiol subfamily.
  
 
 0.977
CG31126
Uncharacterized protein; It is involved in the biological process described with: transcription, DNA-templated; Belongs to the BolA/IbaG family.
   
 
 0.970
CIAPIN1
Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]
    
 
 0.962
CG33785
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
   
  
 0.810
CG13623
GEO08971p1; 2 iron, 2 sulfur cluster binding; structural molecule activity; 4 iron, 4 sulfur cluster binding; iron ion binding. It is involved in the biological process described with: protein maturation; protein maturation by [4Fe-4S] cluster transfer; iron-sulfur cluster assembly.
   
 
 0.798
IscU
Iron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.
      
 0.794
CG8043
GH14121p; RNA binding. It is involved in the biological process described with: iron-sulfur cluster assembly.
      
 0.776
Fdx1
Adrenodoxin-like protein 1, mitochondrial; Required for ecdysteroidogenesis in the prothoracic gland which is necessary for larval to pupal transition. Belongs to the adrenodoxin/putidaredoxin family.
  
  
 0.772
MagR
Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity). Required for maintenance of circadian rhythms under constant darkness.
   
 
 0.765
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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