STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Drep3DNA fragmentation factor-related protein 3 (Drep3) encodes a CIDE domain containing protein that can interact with the proteins encoded by Drep2 and Drep4 via CIDE-CIDE interaction. (266 aa)    
Predicted Functional Partners:
Drep4
DNA fragmentation factor-related protein 4 (Drep4) encodes a CIDE domain containing protein that can interact with the proteins encoded by Drep3 and Drep1 via CIDE-CIDE interaction. It is the ortholog of human DFFB, which has a nuclease activity. The Drep4 product might function in apoptotic DNA fragmentation.
    
 0.976
Drep2
DNAation factor-related protein 2, isoform B; DNA fragmentation factor-related protein 2 (Drep2) encodes a protein involved in neuron death regulation.
    
0.945
Drep1
DNAation factor-related protein 1, isoform B; DNA fragmentation factor-related protein 1 (Drep1) encodes a protein that regulates apoptosis.
  
  
0.760
Axud1
AXIN1 up-regulated 1 (Axud1) encodes a nuclear protein required to regulate cell proliferation rates and cell growth in the wing disc.
      
 0.601
Kap-alpha1
Importin subunit alpha; Karyopherin alpha1 (Kap-alpha1) encodes a protein that is involved in spermatogenesis and the nuclear import of the product of yki.
    
  0.520
Dredd
Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family.
     
  0.499
Fs(2)Ket
Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup.
     
  0.499
rept
RuvB-like helicase 2; Acts as a transcriptional coactivator in Wg signaling caused by altered arm signaling. Pont and rept interfere antagonistically with nuclear arm signaling function, and are required to enhance or reduce arm activity, respectively. Also an essential cofactor for the normal function of Myc; required for cellular proliferation and growth.
      
 0.461
Sptr
Sepiapterin reductase (Sptr) encodes a sepiapterin reductase involved in the biosynthesis of tetrahydrobiopterin.
      
 0.441
CG6220
FI06213p; RNA polymerase II complex binding. It is involved in the biological process described with: positive regulation of transcription elongation from RNA polymerase II promoter; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; histone modification; negative regulation of transcription by RNA polymerase II.
      
 0.430
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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