STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG8860Protein transport protein Sec61 gamma-1 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa)    
Predicted Functional Partners:
Sec61beta
Sec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy.
   
 0.995
Sec61alpha
Sec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel.
   
 0.989
Sec61gamma
Protein transport protein Sec61 gamma-2 subunit; Necessary for protein translocation in the endoplasmic reticulum.
  
 
0.964
Sec63
Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation.
    
 
 0.958
Spase12
Signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
   
  
 0.926
CG13426
P-P-bond-hydrolysis-driven protein transmembrane transporter activity; protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation.
  
  
0.905
kud
Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...]
   
   0.866
RpL39
60S ribosomal protein L39; Structural constituent of ribosome. It is involved in the biological process described with: cytoplasmic translation; translation; Belongs to the eukaryotic ribosomal protein eL39 family.
   
   0.865
Trp1
Translocation protein 1, isoform B; Protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation.
   
 
 0.863
fray
Frayed, isoform A; Frayed (fray) encodes a serine/threonine-protein kinase required for axonal ensheathment. It is activated via phosphorylation by the kinase encoded by Wnk. The product of fray contributes to regulating ion transport, canonical Wnt signaling and asymmetric cell division.
   
 
 0.863
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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