STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cuffCutoff (cuff) encodes a protein that interacts with the products of rhi and del in a germline complex that allows noncanonical transcription of dual-strand piRNA clusters. The product of cuff is therefore an integral part of the piRNA response to transposon activity in the germline. In its absence, a DNA damage checkpoint is activated leading to ventralization of the egg and embryo. (384 aa)    
Predicted Functional Partners:
Rat1
Rat1 5'-3' exoribonuclease (Rat1) encodes a member of the 5'-3' exonuclease family. It is required for mRNA processing and mutations cause phenotypes in various cell types, including the nervous system.
   
 
 0.951
Rrp42
IP10364p; AU-rich element binding.
   
   0.871
CG5964
Uncharacterized protein; It is involved in the biological process described with: cilium assembly; establishment of epithelial cell polarity.
   
 
 0.811
CG9018
Uncharacterized protein, isoform A; RNA polymerase II complex binding. It is involved in the biological process described with: mRNA 3'-end processing.
   
 
 0.810
rhi
RE36324p; Rhino (rhi) encodes an ovary-restricted heterochromatin protein 1 gene required for female fertility. It silences germline transposable elements by promoting transcription of the small RNAs encoded in Piwi-RNAclusters.
   
 
 0.737
del
Protein deadlock; Developmental protein involved in oogenesis. Required for germline maintenance, stability of mitotic spindles, localization of patterning determinants, oocyte growth and fusome biogenesis in males and females. Also required for dorso-ventral and antero-posterior patterning of oocyte and eggshell. May be involved in microtubule function during oogenesis. Part of a rhi-dependent transcription machinery that enables the generation of piRNA precursors from heterochromatin while maintaining the suppression of transposon- encoded promoters and enhancers. Component of the RD [...]
    
 
 0.669
CG13251
CCDC66 domain-containing protein; Microtubule binding. It is involved in the biological process described with: retinal rod cell development.
    
 
 0.587
CG15160
Uncharacterized protein, isoform C; RNA polymerase II complex binding. It is involved in the biological process described with: mRNA 3'-end processing.
   
 
 0.587
Amt
Ammonium transporter (Amt) encodes a protein required for ammonia detection.
      
 0.491
CG8414
Polynucleotide 5'-hydroxyl-kinase NOL9; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily.
   
 
 0.479
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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