STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG30020LD40262p; Zinc ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding; transcription regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; regulation of gene expression. (1309 aa)    
Predicted Functional Partners:
CG13287
Uncharacterized protein, isoform B; Transcription corepressor activity; nucleic acid binding; chromatin binding. It is involved in the biological process described with: regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated.
      
 0.834
CG12219
LD26135p; Zinc ion binding; DNA-binding transcription factor activity; transcription regulatory region sequence-specific DNA binding; DNA binding. It is involved in the biological process described with: regulation of gene expression; regulation of transcription, DNA-templated.
   
  
 0.680
CG14451
UT01871p; Nucleic acid binding.
      
 0.680
CG4820
Uncharacterized protein; DNA-binding transcription factor activity; zinc ion binding; DNA binding. It is involved in the biological process described with: regulation of gene expression; regulation of transcription, DNA-templated.
      
 0.679
Odj
LD33778p; DNA binding; zinc ion binding. It is involved in the biological process described with: heterochromatin organization involved in chromatin silencing.
   
  
 0.668
Hr78
Hormone-receptor-like in 78 (Hr78) encodes a protein induced above a basal level by 20-hydroxyecdysone. Hr78 mutants die during mid-larval stages with defects in molting of the tracheal cuticle; Belongs to the nuclear hormone receptor family. NR2 subfamily.
    
 
 0.612
HLH3B
Helix loop helix protein 3B; Protein dimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
 
 0.605
Kcmf1
E3 ubiquitin-protein ligase Kcmf1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the E2 enzyme Unc6 and the putative E3 ligases poe and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK.
      
 0.603
Br140
Bromodomain-containing protein, 140kD (Br140) encodes a histone acetyltransferase that is a component of the Enok complex, which interacts with the product of elg1 via Br140 to promote the G1/S transition via proliferating cell nuclear antigen (PCNA) unloading.
   
 
 0.569
Chrac-14
DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Histone-like protein which promotes nucleosome sliding of ATP-dependent nucleosome remodeling complexes. Part of the chromatin-accessibility complex (CHRAC) which uses energy/ATP to increase the general accessibility of DNA in chromatin. As an heterodimer with Chrac-16, binds DNA and facilitates nucleosome sliding by Acf. Has a role in DNA damage response by preventing cid mislocalization to chromatin [...]
   
  
 0.500
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.