STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
selProtein seele; Involved in embryonic dorsal-ventral patterning which is generated by a series of serine protease processing events where gd processes snk which cleaves ea which then processes spz into the activating ligand for the Toll receptor. Required during this process for the secretion of ea from the developing embryo into the perivitelline space and for ea processing. Belongs to the canopy family. (189 aa)    
Predicted Functional Partners:
CG4133
RE51073p; Nucleic acid binding.
      
 0.791
Pmm2
Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.
   
    0.686
CG31883
Uncharacterized protein; It is involved in the biological process described with: multicellular organism reproduction.
      
 0.670
CG10550
Uncharacterized protein, isoform B.
      
 0.670
CG44296
Uncharacterized protein; Cytochrome-c oxidase activity. It is involved in the biological process described with: mitochondrial electron transport, cytochrome c to oxygen.
      
 0.669
CG17807
Fe2OG dioxygenase domain-containing protein; Nucleic acid binding; tRNA (uracil) methyltransferase activity; 2-oxoglutarate-dependent dioxygenase activity. It is involved in the biological process described with: tRNA methylation; oxidation-reduction process; tRNA wobble uridine modification.
      
 0.666
Sap-r
Saposin-related, isoform A; Saposin-related (Sap-r) encodes the single protein precursor of several sphingolipid activator proteins (Saposins). Loss of Sap-r leads to the accumulation of sphingolipids in lysosomes, resulting in lysosomal dysfunction, defective lipid homeostasis and neurodegeneration.
      
 0.637
CNPYb
Canopy b; Signaling receptor binding; chaperone binding. It is involved in the biological process described with: chaperone-mediated protein folding.
   
  
 0.628
Sgt
Small glutamine-rich tetratricopeptide containing protein (Sgt) encodes a protein involved in the regulation of the protein folding mediated by chaperones.
   
  
 0.606
CG8399
Putative ferric-chelate reductase 1 homolog; Putative ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Belongs to the FRRS1 family.
      
 0.606
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.