STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pdrg1Pdrg1 prefoldin-like subunit. (132 aa)    
Predicted Functional Partners:
Pfdn2
Probable prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.
   
 
 0.996
Uxt
Uxt prefoldin-like subunit (Uxt) encodes a protein that suppresses growth of larval neuromuscular junctions via an unknown mechanism.
   
 
 0.994
Pfdn6
Probable prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.
   
 
 0.992
Wdr92
WD repeat domain 92; Protein domain specific binding; ubiquitin binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade.
    
 
 0.989
Rpb5
Rpb5, isoform A; DNA-directed 5'-3' RNA polymerase activity; RNA polymerase III activity; RNA polymerase II activity; RNA polymerase I activity; DNA binding. It is involved in the biological process described with: tRNA transcription by RNA polymerase III; transcription by RNA polymerase II; transcription by RNA polymerase I.
   
 
 0.920
spag
FI17138p1; Spaghetti (spag) encodes a TPR domain-containing co-chaperone that associates with Hsp70 and Hsp90 to regulate their activity in macromolecular complexes like RNA polymerase, ribonucleoproteins and Phosphatidyl-Inositol 3-kinase-related kinases. It has been shown to regulate the product of dco levels, with consequences for circadian rhythms and apoptosis.
    
 
 0.917
Pih1D1
PIH1 domain containing 1, isoform D.
   
 
 0.888
Surf6
Surfeit locus protein 6 homolog; Involved in a nucleolar function; Belongs to the SURF6 family.
   
  
 0.812
Pfdn4
Probable prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.
   
 
 0.705
uri
Unconventional prefoldin RPB5 interactor-like protein; Inhibits the activity of serine/threonine-protein phosphatases flw/PP1beta9C and Pp1-87B. Required for germ line cell viability and differentiation, normal transcriptional activity and maintenance of DNA integrity.
   
 
 0.694
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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