| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ask1 | CG1513 | FBpp0289484 | FBpp0087535 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | 0.435 |
| Ask1 | CG33523 | FBpp0289484 | FBpp0303152 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | Uncharacterized protein, isoform F. | 0.451 |
| Ask1 | CG9205 | FBpp0289484 | FBpp0072517 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | LD10220p. | 0.425 |
| Ask1 | RanGAP | FBpp0289484 | FBpp0080775 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.477 |
| Ask1 | Sk2 | FBpp0289484 | FBpp0072854 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | 0.420 |
| Ask1 | cert | FBpp0289484 | FBpp0076440 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.420 |
| Ask1 | l(2)k01209 | FBpp0289484 | FBpp0086069 | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | ATP binding; kinase activity; uridine kinase activity. It is involved in the biological process described with: nucleoside metabolic process; pyrimidine-containing compound salvage. | 0.458 |
| CG1513 | Ask1 | FBpp0087535 | FBpp0289484 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | 0.435 |
| CG1513 | CG33523 | FBpp0087535 | FBpp0303152 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Uncharacterized protein, isoform F. | 0.585 |
| CG1513 | CG9205 | FBpp0087535 | FBpp0072517 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | LD10220p. | 0.618 |
| CG1513 | Jhedup | FBpp0087535 | FBpp0086361 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Carboxylic ester hydrolase activity; Belongs to the type-B carboxylesterase/lipase family. | 0.435 |
| CG1513 | Jheh3 | FBpp0087535 | FBpp0085804 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Epoxide hydrolase; Catalyzes juvenile hormone hydrolysis. Belongs to the peptidase S33 family. | 0.434 |
| CG1513 | RanGAP | FBpp0087535 | FBpp0080775 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] | 0.482 |
| CG1513 | Sk2 | FBpp0087535 | FBpp0072854 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Sphingosine kinase 2 (Sk2) encodes a D-erythro-sphingosine kinase that contributes to sphingolipid metabolism, flight performance and ovulation. | 0.429 |
| CG1513 | cert | FBpp0087535 | FBpp0076440 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Ceramide transfer protein (cert) encodes a protein involved in determination of lifespan. Mutant flies present accelerated aging due to oxidative stress. | 0.431 |
| CG1513 | l(2)k01209 | FBpp0087535 | FBpp0086069 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | ATP binding; kinase activity; uridine kinase activity. It is involved in the biological process described with: nucleoside metabolic process; pyrimidine-containing compound salvage. | 0.431 |
| CG1513 | rst | FBpp0087535 | FBpp0310320 | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | Irregular chiasm C-roughest protein; Roughest (rst) encodes a multi-purpose transmembrane protein that is well studied in the fly eye and muscle during development. It interacts with the transmembrane ligand encoded by hbs to guide cell movement. | 0.434 |
| CG33523 | Ask1 | FBpp0303152 | FBpp0289484 | Uncharacterized protein, isoform F. | Apoptotic signal-regulating kinase 1 (Ask1) encodes a serine/threonine kinase that belongs to the MAPK kinase kinase family. In response to various stresses, it phosphorylates MAPK kinases in JNK and p38 MAPK pathways, inducing cellular stress responses including cell death and immune responses. | 0.451 |
| CG33523 | CG1513 | FBpp0303152 | FBpp0087535 | Uncharacterized protein, isoform F. | Oxysterol-binding protein; Sterol transporter activity; sterol binding; lipid binding; Belongs to the OSBP family. | 0.585 |
| CG33523 | CG9205 | FBpp0303152 | FBpp0072517 | Uncharacterized protein, isoform F. | LD10220p. | 0.582 |