| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Glt | Hml | FBpp0079331 | FBpp0075495 | Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth. | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | 0.471 |
| Glt | PPO2 | FBpp0079331 | FBpp0087744 | Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth. | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.546 |
| Glt | Pxn | FBpp0079331 | FBpp0089215 | Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth. | Peroxidasin; Plays a role in extracellular matrix consolidation, phagocytosis and defense. | 0.752 |
| Glt | Spn27A | FBpp0079331 | FBpp0305543 | Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth. | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] | 0.439 |
| Had2 | Hayan | FBpp0086628 | FBpp0111913 | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | 0.600 |
| Had2 | PPO1 | FBpp0086628 | FBpp0291497 | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.536 |
| Had2 | PPO2 | FBpp0086628 | FBpp0087744 | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.633 |
| Had2 | Spn27A | FBpp0086628 | FBpp0305543 | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] | 0.465 |
| Hayan | Had2 | FBpp0111913 | FBpp0086628 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Beta hydroxy acid dehydrogenase 2; 3-hydroxyacyl-CoA dehydrogenase activity. It is involved in the biological process described with: fatty acid metabolic process; oxidation-reduction process. | 0.600 |
| Hayan | PPO1 | FBpp0111913 | FBpp0291497 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.756 |
| Hayan | PPO2 | FBpp0111913 | FBpp0087744 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.669 |
| Hayan | Spn27A | FBpp0111913 | FBpp0305543 | Serine protease Hayan; Serine protease which, by converting prophenoloxidase 1 (PPO1) into its active form, plays an essential role in the melanization immune response to physical or septic wounding. May function in diverse PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A and Spn28D in the hemolymph, and Spn28D and Spn77BA in the trachea. Also required in the systematic wound response by mediating the redox-dependent activation of the JNK cytoprotective cascade in neuronal tissues after integument wounding; Belongs to the peptidase S1 family. [...] | Serine protease inhibitor 27A; Serine protease inhibitor that functions in embryonic dorsoventral patterning and the melanization immune response. Regulates dorsoventral axis formation during early development by inhibiting the serine protease easter, and is therefore important for restricting activity of the Toll signaling pathway to the ventral part of the embryo. Also plays an essential role in the melanization immune response to both physical wounding and septic infection using certain bacteria and fungi. Negatively regulates the Hayan- dependent prophenoloxidase 1 (PPO1)-activatin [...] | 0.727 |
| Hml | Glt | FBpp0075495 | FBpp0079331 | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | Glutactin (Glt) encodes a secreted protein that belongs to the family of cholinesterase/carboxylesterase-like proteins but lacks the catalytically active residues. It forms part of the basement membrane and regulates axonal outgrowth. | 0.471 |
| Hml | NimC1 | FBpp0075495 | FBpp0310237 | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | Nimrod C1, isoform B; It is involved in the biological process described with: defense response to bacterium; phagocytosis. | 0.719 |
| Hml | PPO1 | FBpp0075495 | FBpp0291497 | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.578 |
| Hml | PPO2 | FBpp0075495 | FBpp0087744 | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.702 |
| Hml | Pxn | FBpp0075495 | FBpp0089215 | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | Peroxidasin; Plays a role in extracellular matrix consolidation, phagocytosis and defense. | 0.746 |
| NimC1 | Hml | FBpp0310237 | FBpp0075495 | Nimrod C1, isoform B; It is involved in the biological process described with: defense response to bacterium; phagocytosis. | Hemolectin, isoform A; Hemolectin (Hml) encodes a large multidomain protein produced by hemocytes and involved in the clotting reaction. | 0.719 |
| NimC1 | PPO1 | FBpp0310237 | FBpp0291497 | Nimrod C1, isoform B; It is involved in the biological process described with: defense response to bacterium; phagocytosis. | Prophenoloxidase 1 (PPO1) encodes a protein produced by crystal cells (a type of hemocyte cell) and is involved in the melanization reaction, notably upon wounding. It is thought to be activated by proteolytic cleavage by the serine protease encoded by Hayan. | 0.642 |
| NimC1 | PPO2 | FBpp0310237 | FBpp0087744 | Nimrod C1, isoform B; It is involved in the biological process described with: defense response to bacterium; phagocytosis. | Prophenoloxidase 2 (PPO2) encodes a protein stored in large crystals in the crystal cells (a type of hemocyte cell) that is involved in the melanization reaction. It contributes to melanization around wounds and wasp encapsulation and is thought to be activated by proteolytic cleavage by the product of Hayan. | 0.657 |