STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cyp4ad1Probable cytochrome P450 4ad1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (516 aa)    
Predicted Functional Partners:
GstD9
Glutathione transferase activity. It is involved in the biological process described with: glutathione metabolic process.
      
 0.461
spok
Spookier (spok) encodes a cytochrome P450 involved in ecdysteroid biosynthesis that is expressed primarily in the prothoracic gland and is localized in the endoplasmic reticulum. Genetic evidence suggests that the product of spok acts with the products of sro and Cyp6t3 to catalyze conversion of 7 dehydrocholesterol to delta4, diketol during the ecdysone biosynthetic pathway.
  
 
 0.460
Cyp309a1
Probable cytochrome P450 309a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.455
Cyp12a4
Probable cytochrome P450 12a4, mitochondrial; Has a role in resistance to insecticide lufenuron, but no other insecticides.
  
 
0.439
Cyp12a5
Probable cytochrome P450 12a5, mitochondrial; Heme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.
  
 
0.427
Cyp6d5
Probable cytochrome P450 6d5; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.425
Cyp12c1
Probable cytochrome P450 12c1, mitochondrial; Heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; Belongs to the cytochrome P450 family.
  
   
0.415
Cyp9h1
Probable cytochrome P450 9h1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.410
Cyp6t1
Probable cytochrome P450 6t1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.402
Cyp304a1
Probable cytochrome P450 304a1; May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
  
 
0.401
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.