STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CG1603FI01116p; Transcription coactivator activity; nucleic acid binding. It is involved in the biological process described with: regulation of gene expression; positive regulation of transcription by RNA polymerase II. (586 aa)    
Predicted Functional Partners:
CG3919
Uncharacterized protein, isoform C; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
  
 0.840
brwl
Brickwall, isoform A; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
   
  
 0.663
gfzf
GST-containing FLYWCH zinc-finger protein (gfzf) encodes encodes a glutathione binding protein that is predicted by phylogeny to have glutathione transferase activity; Belongs to the GST superfamily.
   
  
 0.636
PTP-ER
Protein tyrosine phosphatase-ERK/Enhancer of Ras1 (PTP-ER) encodes a phosphatase required for mitosis. It is involved in RAS/MAPK signaling regulation and eye development.
   
  
 0.630
Fip1
Factor interacting with poly(A) polymerase 1; Myosin binding. It is involved in the biological process described with: mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; pre-mRNA cleavage required for polyadenylation; mRNA 3'-end processing by stem-loop binding and cleavage.
   
  
 0.612
rl
Mitogen-activated protein kinase ERK-A; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway to regulate poliferation, differentiation and effect cell fate decisions in various tissues. Required downstream of phl/Raf in the sev/sevenless, tor/torso, and EGF receptor homolog Egfr signal transduction pathways. Required for embryonic epithelial tissue repair. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.
   
 
 0.612
CG13204
FI20150p1; CG13204 encodes a protein predicted to be a transcriptional regulator. CG13204 overexpression can partially rescue hng1 loss of function, suggesting either epistasis or an overlaping function between hng1 and CG13204.
      
 0.601
az2
RE20796p; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; zinc ion binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific. It is involved in the biological process described with: regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated.
   
 
0.551
stwl
Stonewall, isoform A; Stonewall (stwl) encodes a protein that is associated with heterochromatin and modifies levels of trimethylated H3K27 and H3K9. stwl product is required for maintenance of female germline stem cells and for survival of genotoxic stress induced by DNA replication inhibition.
   
  
 0.546
CG4404
FI04833p; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II.
      
 0.491
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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