node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CecA1 | CecB | FBpp0084977 | FBpp0085002 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | 0.901 |
CecA1 | CecC | FBpp0084977 | FBpp0084980 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Cecropin-C; Cecropin C (CecC) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is strongly expressed at the pupal stage. | 0.901 |
CecA1 | Dif | FBpp0084977 | FBpp0290792 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Dorsal-related immunity factor Dif; Mediates an immune response in larvae. DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1. Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that downregulates Spn27A in response to infection. Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates dev [...] | 0.978 |
CecA1 | DptA | FBpp0084977 | FBpp0085802 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Diptericin A (DptA) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway; Belongs to the attacin/sarcotoxin-2 family. | 0.948 |
CecA1 | DptB | FBpp0084977 | FBpp0085803 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. | 0.948 |
CecA1 | Dredd | FBpp0084977 | FBpp0113052 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family. | 0.484 |
CecA1 | IKKbeta | FBpp0084977 | FBpp0293344 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Inhibitor of nuclear factor kappa-B kinase subunit beta; Required for the activation of the NF-kappa-B factor Relish (Rel) by acting as an essential signaling component in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation, which is required for direct activation of Rel. Phosphorylates inhibitors of NF- kappa-B (cact) thus leading to the dissociation of the inhibitor/NF- kappa-B complex and ultimately the degradation of the NF-kappa-B inhibitor. Essential for antibacterial immune response. | 0.430 |
CecA1 | PGRP-LB | FBpp0084977 | FBpp0297234 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Peptidoglycan recognition protein LB (PGRP-LB) encodes a secreted protein with an amidase activity that scavenges DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It negatively regulates the immune deficiency pathway; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.679 |
CecA1 | Rel | FBpp0084977 | FBpp0088375 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Nuclear factor NF-kappa-B p110 subunit; Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo sig [...] | 0.983 |
CecA1 | imd | FBpp0084977 | FBpp0311815 | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | Protein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...] | 0.913 |
CecB | CecA1 | FBpp0085002 | FBpp0084977 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | 0.901 |
CecB | CecC | FBpp0085002 | FBpp0084980 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Cecropin-C; Cecropin C (CecC) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is strongly expressed at the pupal stage. | 0.985 |
CecB | Dif | FBpp0085002 | FBpp0290792 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Dorsal-related immunity factor Dif; Mediates an immune response in larvae. DIF binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of the immunity gene CECA1. Involved in the melanization immune response to bacterial challenge, possibly by acting in a Toll signaling pathway that downregulates Spn27A in response to infection. Part of a signaling pathway involving NF-kappa-B (rel) and Toll-related receptors, that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates dev [...] | 0.961 |
CecB | DptA | FBpp0085002 | FBpp0085802 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Diptericin A (DptA) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway; Belongs to the attacin/sarcotoxin-2 family. | 0.957 |
CecB | DptB | FBpp0085002 | FBpp0085803 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Diptericin B (DptB) encodes an immune inducible antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia. Its expression is regulated at the transcriptional level by the immune deficiency pathway. | 0.965 |
CecB | PGRP-LB | FBpp0085002 | FBpp0297234 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Peptidoglycan recognition protein LB (PGRP-LB) encodes a secreted protein with an amidase activity that scavenges DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It negatively regulates the immune deficiency pathway; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. | 0.740 |
CecB | Rel | FBpp0085002 | FBpp0088375 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Nuclear factor NF-kappa-B p110 subunit; Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo sig [...] | 0.979 |
CecB | imd | FBpp0085002 | FBpp0311815 | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | Protein immune deficiency; Essential for the imd/NF-kappa-B (Imd) humoral and epithelial immune response to Gram-negative bacteria. Functions as an adapter protein that transduces immunity signals from the activation of pathogen recognition receptors (PRRs) by bacterial infection to the Imd signaling pathway. Binding of diaminopimelic acid-type (DAP-type) bacterial peptidoglycans (PGN) causes multimerization or clustering of PGRP receptors which activate the Imd cascade probably by recruiting imd, Fadd and Dredd to the receptor complex. Once in proximity, Dredd cleaves imd in a Fadd-de [...] | 0.910 |
CecC | CecA1 | FBpp0084980 | FBpp0084977 | Cecropin-C; Cecropin C (CecC) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is strongly expressed at the pupal stage. | Cecropin-A1; Cecropin A1 (CecA1) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is expressed in the fat body during the systemic immune response and in various epithelia, and it is regulated at the transcriptional level, mostly by the immune deficiency pathway; Belongs to the cecropin family. | 0.901 |
CecC | CecB | FBpp0084980 | FBpp0085002 | Cecropin-C; Cecropin C (CecC) encodes an antibacterial peptide with activity against Gram-negative bacteria. It is strongly expressed at the pupal stage. | Cecropin-B; Cecropin B (CecB) encodes an helicoidal antibacterial peptide with activity against Gram-negative bacteria. It is mostly expressed at the pupal stage; Belongs to the cecropin family. | 0.985 |